p53 (Ab-11) (Pantropic) Mouse mAb (PAb1802) | EMD Millipore OP104L-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p53 (Ab-11) (Pantropic) Mouse mAb (PAb1802)

catalog :

OP104L-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

Catalog Number :

OP104L-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p53 (Ab-11) (Pantropic) Mouse mAb (PAb1802)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

7157 (Hu), 22059 (Ms), 24842 (Rt)

Host Name :

Clone :

PAb1802

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-p53 (Ab-11) (Pantropic) Mouse mAb (PAb1802)

Cross Reactivity :

Human, Mouse

Background :

p53 (393 amino acids) exhibits sequence-specific DNA binding, directly interacts with various cellular and viral proteins, and induces cell cycle arrest in response to DNA damage by inducing GADD45, WAF1, and MDM2. p53 is the most commonly mutated gene in human cancer with most mutations occurring in the DNA contact residues. p53 binds damaged DNA non-specifically via its C-terminal 75 amino acids which in turn may be responsible for subsequent activation, sequence-specific DNA binding, and WAF1 induction allowing DNA repair to take place. p53 down regulates bcl-2 expression and up regulates bax expression, but may not always be necessary for apoptosis. In addition to the afore mentioned proteins, two other proteins involved in replication and recombination, RPA and RAD51, also bind p53.

ALT Names :

bbl, bfy, bhy, Delta N p53, FLJ92943, LFS1, MGC112612, P53, Trp53, tumor protein p53

Immunogen :

recombinant, human p53 protein

Specificity :

Recognizes the ~53 kDa wild-type and mutant forms of p53.

Package Size :

100 ug

Uses :

WB, IP

Storage :

Reconstitute the lyophilized antibody with sterile PBS, pH 7.4, or sterile 20 mM Tris-saline (20 mM Tris containing 0.15 M NaCl), pH 7.4, to yield a final concentration of 100 ug/ml; product will be more stable if 0.1% sodium azide is included. Lyophilized antibodies should be reconstituted at 4°C by gradual addition of solvent over a period of 1-2 h with occasional gentle mixing.