Myelin CNPase Mouse mAb (SMI-91) | EMD Millipore NE1020-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Myelin CNPase Mouse mAb (SMI-91)

catalog :

NE1020-100UL

quantity :

100 uL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig st11	Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
immunocytochemistry; mouse; 1:200; fig 6	Beaudet M, Yang Q, Cadau S, Blais M, Bellenfant S, Gros Louis F, et al. High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord. Sci Rep. 2015;5:16763 pubmed publisher
western blot; mouse; fig 6	Rolyan H, Tyurina Y, Hernandez M, Amoscato A, Sparvero L, Nmezi B, et al. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci. 2015;35:12002-17 pubmed publisher

product information

Catalog Number :

NE1020-100UL

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-Myelin CNPase Mouse mAb (SMI-91)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1267 (Hu), 12799 (Ms), 25275 (Rt)

Host Name :

Clone :

SMI-91

Conjugate :

Unpurified

Isotype :

IgG1

Product Description :

Anti-Myelin CNPase Mouse mAb (SMI-91)

Cross Reactivity :

Bovine, Canine, Human, Mouse, Porcine, Rat, Sheep

Background :

Myelin CNPase (2',3'-cyclic nucleotide 3'- phosphodiesterase) is a unique enzyme that is present in cells that elaborate myelin in the central and peripheral nervous systems, i.e. oligodendrocytes and Schwann cells respectively. It is virtually undetectable in other cell types in the nervous system. The enzyme found in mammalian brain (with or without reducing agents) is primarily a mixed dimer of ~94 kDa. The dimer consists of a varied proportion of CNP1 (~46 kDa) and CNP2 (~48 kDa) subunits in various species. CNPase is expressed at high levels in oligodendrocytes and Schwann cells, suggesting a a vital role for this enzyme in the normal function of these cells. These cells are distinguished from most other cells by their ability to synthesize and maintain large amounts of myelin. It is suggested that this enzyme plays a role in the production and maintenance of myelin.

ALT Names :

2, 3''-CYCLIC NUCLEOTIDE 3''-PHOSPHODIESTERASE, CNP1, CNPase, CNPF, CNPI, CNPII, 2',3'-cyclic nucleotide 3' phosphodiesterase

Immunogen :

purified, human myelin CNPase

Specificity :

Recognizes the ~46 kDa and ~48 kDa subunits of the 94 kDa myelin CNPase protein.

Package Size :

100 uL

Uses :

ELISA, IH, WB, IC, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.