Myelin Basic Protein Mouse mAb (SMI-94) | EMD Millipore NE1018-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Myelin Basic Protein Mouse mAb (SMI-94)

catalog :

NE1018-100UL

quantity :

100 uL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; rat; 1:1000	Sevc J, Matiašová A, Kútna V, Daxnerova Z. Evidence that the central canal lining of the spinal cord contributes to oligodendrogenesis during postnatal development and adulthood in intact rats. J Comp Neurol. 2014;522:3194-207 pubmed publisher

product information

Catalog Number :

NE1018-100UL

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-Myelin Basic Protein Mouse mAb (SMI-94)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4155 (Hu), 17196 (Ms), 24547 (Rt)

Host Name :

Clone :

SMI-94

Conjugate :

Unpurified

Isotype :

IgG1

Product Description :

Anti-Myelin Basic Protein Mouse mAb (SMI-94)

Cross Reactivity :

Canine, Human, Monkey, Mouse, Rabbit, Rat

Background :

The myelin sheath is essential for rapid and effective propagation of action potential within the axon. Mutations identified in several myelin-related genes reportedly lead to severe demyelinating neuropathies. Recent evidence also suggests that the autoimmune disease Multiple Sclerosis (MS) is mediated by T cells with specificity for antigens in the myelin sheath. Although myelin in the central nervous system (CNS) and peripheral nervous system (PNS) is structurally similar, it is chemically distinct since oligodendrocytes form myelin in the CNS whereas Schwann cells generate PNS myelin. Myelin proteolipid protein (PLP) is the predominant integral membrane protein in mammalian CNS myelin. In contrast, myelin basic protein (MBP) is localized to the myelin cytoplasm and is highly conserved among species. Both MBP and PLP mediate myelin compaction, whereas thickness is regulated by MBP.

ALT Names :

C76307, Golli, GOLLI-MBP, Hmbpr, MGC99675, Mld, MYELIN BASIC, MYELIN BASIS, R75289, Shi, myelin basic protein

Immunogen :

purified human myelin basic protein

Specificity :

Recognizes the ~21 kDa myelin basic protein (MBP).

Package Size :

100 uL

Uses :

ELISA, IH, WB, IC, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.