5-Methylcytosine Mouse mAb (162 33 D3) | EMD Millipore NA81-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

5-Methylcytosine Mouse mAb (162 33 D3)

catalog :

NA81-50UG

quantity :

50 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, radioimmunoassay, immunohistochemistry - paraffin section

citations: 4

Reference
Huang G, Liu L, Wang H, Gou M, Gong P, Tian C, et al. Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation. iScience. 2020;23:100908 pubmed publisher
Gulmez Karaca K, Kupke J, Brito D, Zeuch B, Thome C, Weichenhan D, et al. Neuronal ensemble-specific DNA methylation strengthens engram stability. Nat Commun. 2020;11:639 pubmed publisher
Salmina K, Huna A, Inashkina I, Belyayev A, Krigerts J, Paštová L, et al. Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells. Nucleus. 2017;8:205-221 pubmed publisher
Ahsan S, Raabe E, Haffner M, Vaghasia A, Warren K, Quezado M, et al. Increased 5-hydroxymethylcytosine and decreased 5-methylcytosine are indicators of global epigenetic dysregulation in diffuse intrinsic pontine glioma. Acta Neuropathol Commun. 2014;2:59 pubmed publisher

product information

Catalog Number :

NA81-50UG

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-5-Methylcytosine Mouse mAb (162 33 D3)

Product Type :

Antibodies

Clonality :

Monoclonal

Host Name :

Clone :

162 33 D3

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-5-Methylcytosine Mouse mAb (162 33 D3)

Cross Reactivity :

A Broad Range Of Species

Background :

DNA methylation plays an important role in gene regulation. Methylation of gene-promoter regions leads to loss of function while DNA demethylation can lead to gain of function. Alterations in DNA methylation may play an important role in carcinogenesis. DNA methylation varies according to tissue type. In some cancers types such as Wilms tumor and colon adenocarcinoma have a decrease in global DNA methylation. In contrast other cancers such as breast cancer have DNA hypermethylation. Changes in global DNA methylation status may be useful early markers for the detection of premalignant lesions.

ALT Names :

5-Methylcytosine Mouse mAb (162 33 D3)

Immunogen :

5-methylcytosine conjugated to ovalbumin

Specificity :

Recognizes 5-methylcytosine.

Package Size :

50 ug

Uses :

ELISA, FC, IH, WB, IF, IH(P), RIA

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.