p14ARF (Ab-2) Mouse mAb (14PO2) | EMD Millipore NA70-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p14ARF (Ab-2) Mouse mAb (14PO2)

catalog :

NA70-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

NA70-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p14ARF (Ab-2) Mouse mAb (14PO2)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1029 (Hu), 12578 (Ms), 25163 (Rt)

Host Name :

Clone :

14PO2

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-p14ARF (Ab-2) Mouse mAb (14PO2)

Cross Reactivity :

Human

Background :

The INK4alpha-ARF locus encodes two unrelated proteins both of which function in tumor suppression. p14ARF arrests the cell cycle in a p53-dependent manner. It binds to mdm2 and promotes the rapid degradation of mdm2 protein. This interaction is mediated by the exon 1-beta-encoded N-terminal domain of p14ARF and a C-terminal region of mdm2. ARF-mediated mdm2 degradation is associated with mdm2 modification and concurrent p53 stabilization and accumulation. Deletion of the ARF-INK4alpha locus simultaneously impairs both the INK4alpha-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways.

ALT Names :

ARF, ARF-INK4a, CDK4I, CDKN2, CMM2, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, INK4, INK4A, INK4a-ARF, Ink4a/Arf, MLM, MTS1, p14, p14/ARF, p14ARF, P16, p19ARF, PCTR1, TP16, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Immunogen :

recombinant, human p14 ARF (p16beta)

Specificity :

Recognizes the ~14 kDa p14 ARF protein.

Package Size :

100 ug

Uses :

WB, IF, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.