p16 (Ab-1) Mouse mAb (DCS-50.1/H4) | EMD Millipore NA29-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p16 (Ab-1) Mouse mAb (DCS-50.1/H4)

catalog :

NA29-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

NA29-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p16 (Ab-1) Mouse mAb (DCS-50.1/H4)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1029 (Hu), 12578 (Ms), 25163 (Rt)

Host Name :

Clone :

DCS-50.1/H4

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-p16 (Ab-1) Mouse mAb (DCS-50.1/H4)

Cross Reactivity :

Human

Background :

Various cyclin dependent kinases (CDKs) are critical for progression through the G1 phase of the cell cycle, and the enzymatic activity of CDKs is dependent upon specific association with G1 cyclins. The active cyclin/CDK complex can be inhibited by a number of different inhibitor proteins including the p16 product of the Multiple Tumor Suppressor 1 gene (MTS1). p16 was initially identified as a component of cyclin/CDK complexes and shown to specifically inhibit CDK4, thus earning the name p16INK4. Independent studies have demonstrated that the gene encoding p16 is commonly deleted in many different tumor cell lines. Recent evidence implicates the p16 protein in the Retinoblastoma pathway for control of cell growth and proliferation and demonstrates that p16 can function as a tumor suppressor protein to G1-arrest cells. p16 is also known as p16MTS1, and p16CDK4I. The gene maps to human chromosome 9p21 and has been named MTS1 or CDKN2.

ALT Names :

ARF, ARF-INK4a, CDK4I, CDKN2, CMM2, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, INK4, INK4A, INK4a-ARF, Ink4a/Arf, MLM, MTS1, p14, p14/ARF, p14ARF, P16, p19ARF, PCTR1, TP16, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Immunogen :

recombinant, human p16

Specificity :

Recognizes the ~16 kDa p16 protein.

Package Size :

100 ug

Uses :

Storage :

Do not freeze