PKN2, clone 1D1 Antibody | EMD Millipore MABT496 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PKN2, clone 1D1 Antibody

catalog :

MABT496

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D1

The same clone is also sold as:

Invitrogen: MA5-15887
LifeSpan Biosciences: LS-C169402
MilliporeSigma: SAB5300224
Abnova: MAB10301
OriGene: AM06663SU-N
ProMab: 30252
Novus Biologicals: NBP2-37573

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, flow cytometry

product information

Catalog Number :

MABT496

Subcategory :

Cell Structure

Product Name :

Anti-PKN2, clone 1D1 Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q16513

Host Name :

Mouse

Antigen :

PKN2

Clone :

1D1

Conjugate :

Ascites

Purification Method :

Unpurified

Product Description :

Anti-PKN2, clone 1D1 Antibody

Cross Reactivity :

Human, Rat, Mouse, Monkey

Background :

Serine/threonine-protein kinase N2, also known as Protein kinase C-like 2 or Protein-kinase C-related kinase 2, and encoded by the gene name PKN2/PRK2/PRKCL2, is a PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. PKN2 has been shown to play an important role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Protein-kinase-C-related kinases (PRKs) are part of the lipid-regulated protein kinases (PKC) which also include liver PAK & PKN. Human PRK1 and PRK2 share structurally similar catalytic domains, but less similar N-terminal regulatory regions suggesting different regulatory domain functions. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in adult tissues. Additionally, the serine-threonine kinase PRK2 can be specifically cleaved by caspase-3 (and/or caspase-3-like subfamily members) during apoptosis. PKN2 is expressed in numerous tumor cell lines, especially in bladder tumor cells.

ALT Names :

Serine/threonine-protein kinase N2, Protein kinase C-like 2, Protein-kinase C-related kinase 2, PKN2, PRK2, PRKCL2

Immunogen :

Purified recombinant fragment of human PKN2 expressed in E. Coli

Package Size :

100 µL

Uses :

Western Blotting, ELISA, Immunohistochemistry, Flow Cytometry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.