Desmocollin-2 Antibody, clone 7G6 | EMD Millipore MABT411 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Desmocollin-2 Antibody, clone 7G6

catalog :

MABT411

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7G6

The same clone is also sold as:

Novus Biologicals: NBP2-54519-100ug, NBP2-53378-100ug
Invitrogen: 32-6200
Abnova: MAB14754, MAB14498
Abcam: ab218849, ab218377
Santa Cruz Biotechnology: sc-53485

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

MABT411

Subcategory :

Cell Structure

Product Name :

Anti-Desmocollin-2 Antibody, clone 7G6

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q02487

Host Name :

Mouse

Antigen :

DSC2

Clone :

7G6

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Desmocollin-2 Antibody, clone 7G6

Cross Reactivity :

Human

Background :

Desmocollin-2, also known as Desmocollin-3 or Desmosomal glycoprotein II, or Desmosomal glycoprotein III, and encoded by the gene DSC2/CDHF2/DSC3, is a component of intercellular desmosome junctions. Desmocollin-2 is involved in the interaction of plaque proteins and intermediate filaments that mediate cell-cell adhesion and interacts with DSP, PKP2 and JUP proteins. Additionally, Desmocollin-2 is important for epidermal cell positioning and stratification because it mediates the differential adhesiveness between cells that express different isoforms. Desmocollin-2 is localized to the cell membrane at cell junctions and desmosomes. Desmocollin-2 is expressed in epithelia, myocardium and lymph nodes. Defects in Desmocollin-2 may be associated with Familial arrhythmogenic right ventricular dysplasia 11 (ARVD11) a congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

ALT Names :

Desmocollin-2, Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, Desmosomal glycoprotein III

Immunogen :

MBP-tagged recombinant protein corresponding to the extracellular domain of human Desmocollin-2.

Package Size :

100 μg

Uses :

Western Blotting, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt