Integrin Beta1, clone AIIB2 (Azide Free) | EMD Millipore MABT409 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin Beta1, clone AIIB2 (Azide Free)

catalog :

MABT409

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

AIIB2

The same clone is also sold as:

Developmental Studies Hybridoma Bank: AIIB2

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:200; loading ...; fig 6a	Zhao Q, Busch B, Jiménez Soto L, Ishikawa Ankerhold H, Massberg S, Terradot L, et al. Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation. PLoS Pathog. 2018;14:e1007359 pubmed publisher
immunohistochemistry; mouse; fig 2	Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016;22:497-505 pubmed publisher
	Tian T, Li C, Fu X, Wang S, Lu J, Guo H, et al. β1 integrin-mediated multicellular resistance in hepatocellular carcinoma through activation of the FAK/Akt pathway. J Int Med Res. 2018;46:1311-1325 pubmed publisher
	Soriano Castell D, Chavero A, Rentero C, Bosch M, Vidal Quadras M, Pol A, et al. ROCK1 is a novel Rac1 effector to regulate tubular endocytic membrane formation during clathrin-independent endocytosis. Sci Rep. 2017;7:6866 pubmed publisher

product information

Catalog Number :

MABT409

Subcategory :

Cell Structure

Product Name :

Anti-Integrin Beta1, clone AIIB2 (Azide Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05556

Host Name :

Rat

Antigen :

ITGB1

Clone :

AIIB2

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Integrin Beta1, clone AIIB2 (Azide Free)

Cross Reactivity :

Human

Background :

Integrin beta-1, also known as Fibronectin receptor subunit beta (FNRB), and Glycoprotein IIa (GPIIA), is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.

ALT Names :

Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein Iia, GPIIA, VLA-4 subunit beta, CD29

Immunogen :

Whole cells corresponding to human Integrin Beta1, clone AIIB2 (Azide Free).

Package Size :

100 μg

Uses :

Western Blotting, Immunocytochemistry, Activity Assay, Immunoprecipitation, Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.