Anoctamin-1/TMEM16A Antibody, clone 5F8.1 | EMD Millipore MABT379 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Anoctamin-1/TMEM16A Antibody, clone 5F8.1

catalog :

MABT379

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5F8.1

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABT379

Subcategory :

Cell Structure

Product Name :

Anti-Anoctamin-1/TMEM16A Antibody, clone 5F8.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q5XXA6

Host Name :

Mouse

Antigen :

ANO1

Clone :

5F8.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Anoctamin-1/TMEM16A Antibody, clone 5F8.1

Cross Reactivity :

Human

Background :

Discovered on gastrointestinal stromal tumors protein 1 (Dog1), also known as Anoctamin-1/TMEM16A, is a novel multi-pass membrane protein belonging to the anoctamin family. Anoctamin-1/TMEM16A functions as a Ca2+-activated Cl- channel and is a required component of tracheal development. Expression of Anoctamin-1/TMEM16A is elevated in the gastrointestinal stromal tumors (GISTs), KIT signaling-driven mesenchymal tumors of the GI tract. It is also expressed at more moderate levels in epithelia from foregut, kidney, lung, pancreas and salivary glands. Recent studies suggest that it may serve a roll as a diagnostic marker in the classification of GISTs.

ALT Names :

Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2

Immunogen :

GST-tagged recombinant protein corresponding to the N-terminal cytoplasmic domain of human Anoctamin-1/TMEM16A.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt