CD226/DNAM-1 Antibody, clone NewE1 (Azide Free) | EMD Millipore MABT341 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD226/DNAM-1 Antibody, clone NewE1 (Azide Free)

catalog :

MABT341

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

NewE1

reactivity :

human

application :

western blot, immunoprecipitation

product information

Catalog Number :

MABT341

Subcategory :

Cell Structure

Product Name :

Anti-CD226/DNAM-1 Antibody, clone NewE1 (Azide Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15762

Host Name :

Mouse

Antigen :

CD226

Clone :

NewE1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-CD226/DNAM-1 Antibody, clone NewE1 (Azide Free)

Cross Reactivity :

Human

Background :

CD226/DNAM1 is a T cell expressed plasma membrane receptor protein that plays multiple roles in lymphocyte signaling, intercellular adhesion, lymphokine secretion and cytotoxic T-cell and NK cell mediated killing. CD226 activates natural killer (NK) cell-mediated cytotoxicity and is a key player in the immune synapse between killer T cells and targets. Also, because it recognizes CD155 and nectins CD226/DNAM1 is being examined as a potential anti-cancer agent because soluble CD226 directly inhibits tumor growth by binding CD155 expressed on tumor cells and down regulating proliferation. CD226/DNAM-1 is expressed on Th1, but not Th2 or Th0 cells, it is also expressed on NK cells, CD8+ T-cells, but not developing T cells. CD226/DNAM-1 is also expressed on monocytes and platelets.

ALT Names :

CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD_antigen=CD226

Immunogen :

Recombinant protein corresponding to human CD226/DNAM-1.

Package Size :

100 μg

Uses :

Western Blotting, Immunoprecipitation, Activity Assay

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.