E-cadherin Antibody, clone DECMA-1 | EMD Millipore MABT26 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

E-cadherin Antibody, clone DECMA-1

catalog :

MABT26

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

DECMA-1

The same clone is also sold as:

Invitrogen: 53-3249-80, 14-3249-80, 53-3249-82, 16-3249-85, 13-3249-82, 16-3249-050, 46-3249-82, 50-3249-82, 16-3249-025, 16-3249-38, 14-3249-82, 16-3249-82, 13-3249-80, 50-3249-80
Santa Cruz Biotechnology: sc-59778
BioLegend: 147315, 147316, 147317, 147312, 147310, 147311, 147318, 147306, 147302, 147301, 147313, 147314, 147319, 147303, 147309, 147308, 147307, 147304
Novus Biologicals: NB120-11512SS
MilliporeSigma: U3254
Abcam: ab11512
GeneTex: GTX11512

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:100; loading ...; fig 5b	Kuo W, Hwu L, Wu C, Lee J, Chang C, Liu R. STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer. Theranostics. 2017;7:647-663 pubmed publisher
western blot; human	Picot N, Guerrette R, Beauregard A, Jean S, Michaud P, Harquail J, et al. Mammaglobin 1 promotes breast cancer malignancy and confers sensitivity to anticancer drugs. Mol Carcinog. 2016;55:1150-62 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:50; fig 3	de Jong P, Takahashi N, Peiris M, Bertin S, Lee J, Gareau M, et al. TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP. Mucosal Immunol. 2015;8:491-504 pubmed publisher
	Caballero J, Gervasi M, Veiga M, Dalvit G, Perez Martinez S, Cetica P, et al. Epithelial cadherin is present in bovine oviduct epithelial cells and gametes, and is involved in fertilization-related events. Theriogenology. 2014;81:1189-206 pubmed publisher
	Wang C, Wang H, Pang J, Li L, Zhang S, Song G, et al. Glial cell-derived neurotrophic factor attenuates neuropathic pain in a mouse model of chronic constriction injury: possible involvement of E-cadherin/p120ctn signaling. J Mol Neurosci. 2014;54:156-63 pubmed publisher
	Han X, Zhao L, Lu G, Ge J, Zhao Y, Zu S, et al. Improving outcomes of acute kidney injury using mouse renal progenitor cells alone or in combination with erythropoietin or suramin. Stem Cell Res Ther. 2013;4:74 pubmed publisher
	Voronov D, Gromova A, Liu D, Zoukhri D, Medvinsky A, Meech R, et al. Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration. Invest Ophthalmol Vis Sci. 2013;54:3115-25 pubmed publisher
	Zemans R, McClendon J, Aschner Y, Briones N, Young S, Lau L, et al. Role of ?-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol. 2013;304:L415-27 pubmed publisher
	Barnes E, Kenerson H, Jiang X, Yeung R. Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition. Am J Pathol. 2010;177:1765-78 pubmed publisher
	De Santis G, Miotti S, Mazzi M, Canevari S, Tomassetti A. E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells. Oncogene. 2009;28:1206-17 pubmed publisher
	Espada J, Galaz S, Sanz Rodriguez F, Blazquez Castro A, Stockert J, Bagazgoitia L, et al. Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes. J Cell Physiol. 2009;219:84-93 pubmed publisher
	Nagaoka M, Ise H, Harada I, Koshimizu U, Maruyama A, Akaike T. Embryonic undifferentiated cells show scattering activity on a surface coated with immobilized E-cadherin. J Cell Biochem. 2008;103:296-310 pubmed
	Kania G, Corbeil D, Fuchs J, Tarasov K, Blyszczuk P, Huttner W, et al. Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells. 2005;23:791-804 pubmed

product information

Catalog Number :

MABT26

Subcategory :

Cell Structure

Product Name :

Anti-E-cadherin Antibody, clone DECMA-1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09803

Host Name :

Rat

Antigen :

E-cadherin

Clone :

Decma-1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-E-cadherin Antibody, clone DECMA-1

Cross Reactivity :

Human;Mouse

Background :

Cadherins are a family of transmembrane glycoproteins involved in Ca2+-dependent cell to cell interactions. The members of the family are differentially expressed in various tissues and function in the maintenance of tissue integrity, morphogenesis, and migration. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin), neural cadherin (N-cadherin), placental cadherin (P-cadherin) and retinal cadherin (R-cadherin). Type II include kidney cadherin (K-cadherin) and osteoblast cadherin (OB-cadherin). One of the best characterized cadherins is E-cadherin (epithelial cadherin or cadherin-1). It consists of calcium-binding extracellular domains responsible for interactions with other E-cadherin molecules on neighboring cells and interaction with integrin alphaEbeta7. The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas, E-cadherin is frequently downregulated, consistent with its function of an invasion suppressor in normal epithelia.

ALT Names :

CAM 120/80;CD324 antigen;Cadherin 1, E-cadherin (epithelial);cadherin 1, type 1;cadherin 1, type 1, E-cadherin (epithelial);calcium-dependent adhesion protein, epithelial;cell-CAM 120/80

Immunogen :

Mouse embryonal carcinoma cell line PCC4

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry;Immunocytochemistry;Immunoprecipitation;Flow Cytometry;Affects Function

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.