E-Cadherin, clone 9E3.1 | EMD Millipore MABT218 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

E-Cadherin, clone 9E3.1

catalog :

MABT218

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9E3.1

reactivity :

human

application :

western blot, flow cytometry

product information

Catalog Number :

MABT218

Subcategory :

Cell Structure

Product Name :

Anti-E-Cadherin, clone 9E3.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P12830

Host Name :

Mouse

Antigen :

CDH1

Clone :

9E3.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-E-Cadherin, clone 9E3.1

Cross Reactivity :

Human

Background :

Cadherins are a family of transmembrane glycoproteins involved in Ca2+-dependent cell to cell interactions. The members of the family are differentially expressed in various tissues and function in the maintenance of tissue integrity, morphogenesis, and migration. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin), neural cadherin (N-cadherin), placental cadherin (P-cadherin) and retinal cadherin (R-cadherin). Type II include kidney cadherin (K-cadherin) and osteoblast cadherin (OB-cadherin). One of the best characterized cadherins is E-cadherin (epithelial cadherin or cadherin-1). It consists of calcium binding extracellular domains responsible for interactions with other E-cadherin molecules on neighboring cells and interaction with integrin alphaEbeta7. The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas E-cadherin is frequently downregulated, which is consistent with its function of an invasion suppressor in normal epithelia.

ALT Names :

Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin

Immunogen :

GST-tagged recombinant protein corresponding to the extracellular domain of human E-Cadherin-1.

Package Size :

100 μg

Uses :

Western Blotting, Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt