Abl (c-, v-, Bcr-) Antibody, clone 24-21 | EMD Millipore MABT203 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Abl (c-, v-, Bcr-) Antibody, clone 24-21

catalog :

MABT203

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24-21

reactivity :

human, Xenopus laevis

application :

western blot, immunocytochemistry

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; Xenopus laevis; 1:1000	Singh A, Winterbottom E, Ji Y, Hwang Y, Daar I. Abelson interactor 1 (ABI1) and its interaction with Wiskott-Aldrich syndrome protein (wasp) are critical for proper eye formation in Xenopus embryos. J Biol Chem. 2013;288:14135-46 pubmed publisher
	Amabile G, Di Ruscio A, Müller F, Welner R, Yang H, Ebralidze A, et al. Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015;6:7091 pubmed publisher
	Simmons M, Serra R, Hermance N, Kelliher M. NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro. Breast Cancer Res. 2012;14:R126 pubmed publisher
	Zaghloul N, Hernandez S, Bae J, Huang J, Fisher J, Lee A, et al. Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma. Int J Oncol. 2009;34:401-7 pubmed
	Kleinmann E, Geimer Le Lay A, Sellars M, Kastner P, Chan S. Ikaros represses the transcriptional response to Notch signaling in T-cell development. Mol Cell Biol. 2008;28:7465-75 pubmed publisher

product information

Catalog Number :

MABT203

Subcategory :

Cell Structure

Product Name :

Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P00519

Host Name :

Mouse

Antigen :

Abl (c-

Clone :

24-21

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Abl (c-, v-, Bcr-) Antibody, clone 24-21

Cross Reactivity :

Human

Background :

c-Abl, v-Abl, and Bcr-abl are ubiquitously expressed non-receptor tyrosine kinases that are involved in a plethora of cellular processes. c-Abl is involved in cytoskeleton remodeling and facilitates cell adhesion and cell motility. c-Abl achieves cytoskeleton remodeling by phosphorylating and activating a wide variety of cytoskeleton-associated proteins such as WASF3, ANXA1, DBN1, DBNL, CTTN, RAPH1, ENAH, MAPT, and PXN. Abl-1 also phosphorylates a number of receptor tyrosine kinases and is involved in regulating levels of EGFR by endocytosis. c-Abl may also play a role in DNA damage response via the ATM pathway, among other cellular processes. Whereas v-Abl is known to be involved in pre-B cell transformation in mice, Bcr-Abl is reported to promote cellular growth in leukemia cells and maintain CML phenotype. Many v-Abl- and Bcr-abl-mediated signaling events have been described; however the complexity and function of these pathways require further elucidation.

ALT Names :

Tyrosine-protein kinase ABL1;Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Proto-oncogene c-Abl;p150

Immunogen :

Recombinant protein corresponding to the carboxyl region of human v-Abl fused with TrpE.

Specificity :

This antibody recognizes the c-terminus of c-Abl, v-Abl, and Bcr-Abl.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt