Kindlin-3 Antibody, clone 181A | EMD Millipore MABT187 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Kindlin-3 Antibody, clone 181A

catalog :

MABT187

quantity :

100 µL

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

181A

reactivity :

human

application :

western blot

product information

Catalog Number :

MABT187

Subcategory :

Cell Structure

Product Name :

Anti-Kindlin-3 Antibody, clone 181A

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q86UX7

Host Name :

Rat

Antigen :

Kindlin-3

Clone :

181A

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Kindlin-3 Antibody, clone 181A

Cross Reactivity :

Human

Background :

Kindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the β chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted.

ALT Names :

Fermitin family homolog 3;Kindlin-3;MIG2-like protein;Unc-112-related protein 2

Immunogen :

His-tagged recombinant protein corresponding to human Kindlin-3.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt