ADAMTS5 Antibody, clone 3A2.1 | EMD Millipore MABT175 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ADAMTS5 Antibody, clone 3A2.1

catalog :

MABT175

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A2.1

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABT175

Subcategory :

Cell Structure

Product Name :

Anti-ADAMTS5 Antibody, clone 3A2.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UNA0

Host Name :

Mouse

Antigen :

ADAMTS5

Clone :

3A2.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-ADAMTS5 Antibody, clone 3A2.1

Cross Reactivity :

Human

Background :

The ADAMTS (A Disintegrin and Metalloprotease with Thrombospondin motifs) family of secreted proteases comprises at least 20 members in mammals, and several members in invertebrates. ADAMTS members resemble the membrane-bound ADAM family of proteases in the presence of a prodomain, a catalytic domain and a disintegrin-like domain. However, ADAMTS members lack a transmembrane domain, and instead contain varying numbers of thrombospondin type I modules. ADAMTS-5, along with ADAMTS-4, cleaves aggrecan between Glu373 and Ala374, a physiological cleavage site in arthritic cartilage. In addition, expression of ADAMTS-5 is elevated in human chondrocytes treated with inflammatory cytokine interleukin-1, but is constitutively expressed in bovine cartilage explants. 70 and 53 kD forms of ADAMTS-5 have been shown to be present at varying ratios in fibroblast-like synoviocytes and extracts of rheumatoid arthritis, osteoarthritis and normal synovial tissue.

ALT Names :

A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, EC 3.4.24.-, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2

Immunogen :

GST-tagged recombinant protein corresponding to the C-terminus of human ADAMTS5.

Package Size :

100 μg

Uses :

Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt