Cytohesin-1 Antibody, clone 7H2 | EMD Millipore MABT14 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cytohesin-1 Antibody, clone 7H2

catalog :

MABT14

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

7H2

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig 4a	Rafiq N, Lieu Z, Jiang T, Yu C, Matsudaira P, Jones G, et al. Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J Cell Biol. 2017;216:181-197 pubmed publisher

product information

Catalog Number :

MABT14

Subcategory :

Cell Structure

Product Name :

Anti-Cytohesin-1 Antibody, clone 7H2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15438

Host Name :

Rat

Antigen :

Cytohesin-1

Clone :

7H2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Cytohesin-1 Antibody, clone 7H2

Cross Reactivity :

Human

Background :

Cytohesin-1 is a guanine nucleotide exchange factor and an integrin binding protein belonging to a closely related group of proteins known as the cytohesion family. Cytohesin-1 contains 2 domains; a C-terminal, pleckstrin homology (PH) domain, and a central, large Sec7 domain. The PH domain serves to mediate the proteins functional regulation and the reversible membrane recruitment. The Sec7 domain acts as the primary regulator for phosphoinositide-dependent membrane attachment of the protein. Cytohesin-1 appears to have an integral role in integrin alphaLbeta2 adhesive function, and in the activation of integrin mediated pathways involved in wound healing, and immune system cell-cell/ cell-matrix interactions. It is highly expressed in natural killer and peripheral T cells. There are two known isoforms produced by alternative splicing.

ALT Names :

cytohesin 1;cytoadhesin 1;CYTOHESIN-1;pleckstrin homology, Sec7 and coiled-coil domains 1;homolog of secretory protein SEC7;PH, SEC7 and coiled-coil domain-containing protein 1;SEC7 homolog B2-1

Immunogen :

Histidine-tagged recombinant protein corresponding to human Cytohesin-1.

Specificity :

The antibody recognizes Cytohesin-1.

Package Size :

100 μg

Uses :

Western Blotting;Immunofluorescence;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt