Pirh2 Antibody, clone 11G8.1 | EMD Millipore MABT123 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Pirh2 Antibody, clone 11G8.1

catalog :

MABT123

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

11G8.1

reactivity :

human, mouse

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 8	Tanaka T, Iino M. Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. Cell Signal. 2015;27:1110-9 pubmed publisher

product information

Catalog Number :

MABT123

Subcategory :

Cell Structure

Product Name :

Anti-Pirh2 Antibody, clone 11G8.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q96PM5

Host Name :

Mouse

Antigen :

Pirh2

Clone :

11G8.1

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Pirh2 Antibody, clone 11G8.1

Cross Reactivity :

Human;Mouse

Background :

Pirh2, also known as Androgen receptor N-terminal-interacting protein or CH-rich-interacting match with PLAG1 or E3 ubiquitin-protein ligase Pirh2 or RING finger protein 199 or Zinc finger protein 363 or p53-induced RING-H2 protein (Pirh2), encoded by the gene RCHY1/ARNIP/CHIMP/PIRH2/RNF199/ZNF363, is an E3 ubiquitin ligase protein that mediates the E3-dependent ubiquitination and proteasomal degradation of a number of important signaling and DNA methylation proteins including p53/TP53, p73, HDAC1 and CDKN1B. Pirh2 also monoubiquitinates the translesion DNA polymerase POLH and contributes to the regulation of the cell cycle progression. Additionally, Pirh2 increases androgen receptor transcription factor activity as well and Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1 proteins. Pirh2 is localized to the cytoplasm and nucleus, and can be found in nucleus speckles. Pirh2 is expressed in all cell types examined and is up-regulated during the S phase of the cell cycle. Pirh2 is expressed at low levels during G phase.

ALT Names :

RING finger and CHY zinc finger domain-containing protein 1;Androgen receptor N-terminal-interacting protein;CH-rich-interacting match with PLAG1;E3 ubiquitin-protein ligase Pirh2;RING finger protein 199;Zinc finger protein 363;p53-induced RING-H2 protein;hPirh2

Immunogen :

GST-tagged recombinant protein corresponding to human Pirh2.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt