Desmoglein-1 Antibody, clone 32-2B | EMD Millipore MABT118 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Desmoglein-1 Antibody, clone 32-2B

catalog :

MABT118

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

32-2B

The same clone is also sold as:

OriGene: TA353151L

reactivity :

human, bovine

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Reference
Nishifuji K, Olivry T, Ishii K, Iwasaki T, Amagai M. IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus. Vet Immunol Immunopathol. 2007;117:209-21 pubmed

product information

Catalog Number :

MABT118

Subcategory :

Cell Structure

Product Name :

Anti-Desmoglein-1 Antibody, clone 32-2B

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q03763

Host Name :

Mouse

Antigen :

Desmoglein-1

Clone :

32-2B

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Desmoglein-1 Antibody, clone 32-2B

Cross Reactivity :

Human

Background :

Desmoglein-1 (DSG1) is a transmembrane glycoprotein belonging to the family of cadherins. It is one of the main structural components of desmosomal junctions which are abundant in tissues undergoing frequent mechanical stress, such as the heart, epidermis, lymphatic endothelial cells, and meninges. The desmoglein-1 subtype is highly expressed in the epidermis. Like other cadherins, desmoglein-1 contains multiple calcium binding sites and a cell-adhesion recognition site which facilitates intercellular adhesions. Desmoglein-1 is regulated by calcium and PKCα signaling, and is also coupled to intermediate filaments of the cytoskeleton. Desmosomes play a critical role in cell and tissue stability, and may contribute to the progression of cancer.

ALT Names :

Desmoglein-1;Desmosomal glycoprotein 1;DG1;DGI;Pemphigus foliaceus antigen

Immunogen :

Bovine Desmoglein-1 from nasal epidermis

Package Size :

100 μg

Uses :

Western Blotting;Immunofluorescence;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt