phospho-p70 S6 Kinase (Thr389) Antibody, clone 10G7.1 | EMD Millipore MABS82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-p70 S6 Kinase (Thr389) Antibody, clone 10G7.1

catalog :

MABS82

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

10G7.1

reactivity :

human

application :

western blot, immunocytochemistry

citations: 4

Reference
Boral D, Liu H, Kenney S, Marchetti D. Molecular Interplay between Dormant Bone Marrow-Resident Cells (BMRCs) and CTCs in Breast Cancer. Cancers (Basel). 2020;12: pubmed publisher
Kang Y, Hsu W, Wu C, Hsin I, Wu P, Yeh K, et al. Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells. Oncotarget. 2017;8:105536-105552 pubmed publisher
Dauner K, Eid W, Raghupathy R, Presley J, Zha X. mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery. J Biol Chem. 2017;292:5737-5747 pubmed publisher
Kubota M, Matsuda Y, Fujimaki S, Osawa M, Wakai T, Nakaya K. Effects of rapamycin on granulation formation in response to centrally doubled coiled stents as a tracheal substitute. J Pediatr Surg. 2013;48:2416-24 pubmed publisher

product information

Catalog Number :

MABS82

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-p70 S6 Kinase (Thr389) Antibody, clone 10G7.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P23443

Host Name :

Mouse

Antigen :

phospho-p70 S6 Kinase (Thr389)

Clone :

10G7.1

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-phospho-p70 S6 Kinase (Thr389) Antibody, clone 10G7.1

Cross Reactivity :

Human;Mouse

Background :

The p70 S6 kinase is a ubiquitous cytoplasmic protein that is activated in response to cytokines, and growth factors including the epidermal growth factor and fibroblast growth factor. It lies downstream of the mTOR/PI3K pathway and is phosphorylated on multiple residues: Thr389, Thr229, Thr421, Ser371, Ser404, Ser411, Ser418, and Ser424. Thr389, Ser371, and Ser404 are located in the linker domain; whereas Thr421, Ser411, Ser418, Ser424 are located in the autoinhibitory domain, and Thr229 is found in the catalytic domain. These sites may be phosphorylated in a hierarchical sequence leading to the activation of the p70 S6 kinase. The p70 S6 kinase phosphorylates the S6 protein on the 40S ribosomal protein (rpS6), and plays a role in multiple processes including regulation of mRNA molecules with 5’-terminal oligopyrimidine tracts, protein synthesis, cell growth, proliferation, and cell survival. The activity of this kinase may be important in diabetes, cancer, and aging.

ALT Names :

Ribosomal protein S6 kinase beta-1;S6K-beta-1;S6K1;70 kDa ribosomal protein S6 kinase 1;Short name=P70S6K1;p70-S6K 1;Ribosomal protein S6 kinase I;Serine/threonine-protein kinase 14A;p70 ribosomal S6 kinase alpha;p70 S6 kinase alpha;p70 S6K-alpha;p70 S6KA

Immunogen :

KLH-conjugated linear peptide corresponding to mouse p70 S6 Kinase phosphorylated at (Thr389).

Specificity :

This antibody recognizes p70 S6 Kinase phosphorylated at (Thr389). This antibody also recognizes isoforms Alpha I and Alpha II.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt