phospho-MAPK 1/2 (Thr203/Ty205) Antibody, clone 14B9.1 | EMD Millipore MABS71 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-MAPK 1/2 (Thr203/Ty205) Antibody, clone 14B9.1

catalog :

MABS71

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14B9.1

reactivity :

human

application :

western blot

product information

Catalog Number :

MABS71

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-MAPK 1/2 (Thr203/Ty205) Antibody, clone 14B9.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P27361

Host Name :

Mouse

Antigen :

phospho-MAPK 1/2 (Thr203/Ty205)

Clone :

14B9.1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-phospho-MAPK 1/2 (Thr203/Ty205) Antibody, clone 14B9.1

Cross Reactivity :

Human

Background :

The extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), also called p44 and p42 MAP kinases, are members of the Mitogen Activated Protein Kinase (MAPK) family of proteins found in all eukaryotes. The 44 kDa ERK1 and the 42 kDa ERK2 are highly homologous and both function in the same protein kinase cascade. For this reason, the two proteins are often referred to collectively as ERK1/2 or p44/p42 MAP kinase. The ERK1/2 signaling cascade has been shown to be a critical regulator of cell differentiation, cell physiology and neuronal function. Aberrant control of ERK1/2 activity has been implicated in a variety of pathological conditions, including cancer and autoimmune diseases, and efficient study methods are in demand. Extracellular signal/mitogen activated protein kinases (erk/MAPK) are a group of proline-directed serine/threonine kinases that are activated by dual phosphorylation of conserved threonine and tyrosine residues within a characteristic T X Y peptide motif. The mitogen-activated kinases erk1 (MAPK1) and erk2 (MAPK2) acquire full enzymatic activity upon phosphorylation of both threonine and tyrosine residues within the sequence motif T E Y.

ALT Names :

Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p44-ERK1

Immunogen :

KLH-conjugated linear peptide corresponding to human MAPK 1/2 phosphorylated at Thr203 and Ty205.

Specificity :

Antibody recognizes dual phosphorylation of MAPK1/2 at Thr203/Tyr204, but this antibody has not been used for the detection of single phosphorylation at either site.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt