Insulin Receptor Antibody, beta subunit, clone CT-3 | EMD Millipore MABS65 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Insulin Receptor Antibody, beta subunit, clone CT-3

catalog :

MABS65

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CT-3

The same clone is also sold as:

Santa Cruz Biotechnology: sc-57342
LifeSpan Biosciences: LS-C24738, LS-C88312, LS-C101322
Enzo Life Sciences: BML-SA432-0100
Invitrogen: MA5-13783, AHR0271

reactivity :

human, mouse

application :

western blot, immunohistochemistry

citations: 3

Reference
Li J, Xu L, Dong H, Huang Z, Zhao Y, Chen G, et al. Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats. J Huazhong Univ Sci Technolog Med Sci. 2013;33:877-885 pubmed publisher
Bobrich M, Schwabe S, Brobeil A, Viard M, Kamm M, Mooren F, et al. PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue. J Obes. 2013;2013:476240 pubmed publisher
Devi L, Alldred M, Ginsberg S, Ohno M. Mechanisms underlying insulin deficiency-induced acceleration of ?-amyloidosis in a mouse model of Alzheimer's disease. PLoS ONE. 2012;7:e32792 pubmed publisher

product information

Catalog Number :

MABS65

Subcategory :

Metabolism

Product Name :

Anti-Insulin Receptor Antibody, beta subunit, clone CT-3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P06213

Host Name :

Mouse

Antigen :

Insulin Receptor

Clone :

CT-3

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Insulin Receptor Antibody, beta subunit, clone CT-3

Cross Reactivity :

Mouse;Human

Background :

The insulin receptor is a tyrosine kinase receptor that when bound to insulin, initiates multiple signal transduction pathways, including JNK, PI 3-kinase, Akt and PKC. Pharmacological intervention of these Insulin R-dependent pathways is of great interest for the treatment of insulin resistance, obesity and diabetes. The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α-chain and a transmembrane and intracellular β-chain, tethered together by disulfide bonds. The β-chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation loop. The overall structure of the IR is highly homologous to the IGF-I Receptor, except in their c-termini, where the two proteins diverge somewhat. The IR signals primarily by phosphorylating the Insulin Receptor Substrate (IRS) family of proteins, which creates docking sites for SH2-domain containing proteins. Insulin signaling is highly dependent on the PI3 Kinase pathway and Akt, which appear to mediate the functions of insulin.

ALT Names :

CD220 antigen;insulin receptor

Immunogen :

Recombinant protein corresponding to the C-terminus of human Insulin Receptor, beta subunit.

Specificity :

This antibody recognizes the C-terminus of human Insulin Receptor, beta subunit.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt