phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2 | EMD Millipore MABS64 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2

catalog :

MABS64

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6E5.2

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:400; fig 2e western blot; human; 1:400; fig 1b	Frank S, Berger P, Ljungman M, Miranti C. Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC. J Cell Sci. 2017;130:1952-1964 pubmed publisher
western blot; mouse	Ogiso H, Taniguchi M, Okazaki T. Analysis of lipid-composition changes in plasma membrane microdomains. J Lipid Res. 2015;56:1594-605 pubmed publisher
western blot; human; 1:500	Daniele S, Da Pozzo E, Zappelli E, Martini C. Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-?B, p38 and JNK. Cell Signal. 2015;27:1609-29 pubmed publisher
	Shen W, Lee S, Araújo J, Chung S, Zhu L, Gillies M. Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Müller cell ablation. Glia. 2014;62:1110-24 pubmed publisher

product information

Catalog Number :

MABS64

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q16539

Host Name :

Mouse

Antigen :

phospho-p38 (Thr180/Tyr182)

Clone :

6E5.2

Conjugate :

Purified

Product Description :

Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2

Cross Reactivity :

Human;Mouse

Background :

The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation.

ALT Names :

mitogen-activated protein kinase 14;cytokine suppressive anti-inflammatory drug binding protein;stress-activated protein kinase 2A;Cytokine suppressive anti-inflammatory drug-binding protein;CSAID-binding protein;MAP kinase MXI2;MAX-interacting protein 2;CSAID-binding protein;Mitogen-activated protein kinase p38 alpha;p38 MAP kinase;p38 mitogen activated protein kinase;MAP kinase p38 alpha;Csaids binding protein

Immunogen :

Linear peptide corresponding to human p38 phosphorylated at Thr180 and Tyr182.

Specificity :

This antibody recognizes p38 when phosphorylated at Thr180 and Tyr182.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt