P40 Antibody, clone 11F12.1 | EMD Millipore MABS519 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

P40 Antibody, clone 11F12.1

catalog :

MABS519

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

11F12.1

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 1b	Yoshida M, Yokota E, Sakuma T, Yamatsuji T, Takigawa N, Ushijima T, et al. Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma. Oncotarget. 2018;9:29220-29232 pubmed publisher

product information

Catalog Number :

MABS519

Subcategory :

Cell Signaling

Product Name :

Anti-P40 Antibody, clone 11F12.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9H3D4

Host Name :

Mouse

Antigen :

TP63

Clone :

11F12.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-P40 Antibody, clone 11F12.1

Cross Reactivity :

Human

Background :

P40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a transcriptional activator or repressor depending upon the target gene and the isoform involved. P40 has multiple isoforms. P40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover P40, developmentally, is required for proper limb formation. P40 is widely expressed in the adult and during development. Some isoforms, such as isoform 10 are primarily expressed in cancerous tissues while others are found only in normal tissues. Mutations in P40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome and Ankyloblepharon-ectodermal defects cleft lip/palate disorder and several more tragic disfiguring syndromes.

ALT Names :

Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51

Immunogen :

KLH-conjugated linear peptide corresponding to human P40.

Package Size :

100 μg

Uses :

Immunohistochemistry (Paraffin), Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt