Keap1 Antibody, clone 144 | EMD Millipore MABS514 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Keap1 Antibody, clone 144

catalog :

MABS514

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

144

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

product information

Catalog Number :

MABS514

Subcategory :

Cell Signaling

Product Name :

Anti-Keap1 Antibody, clone 144

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9Z2X8

Host Name :

Rat

Antigen :

Keap1

Clone :

144

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2bκ

Product Description :

Anti-Keap1 Antibody, clone 144

Cross Reactivity :

Human, Mouse

Background :

KEAP1 is an important adapter protein important in regulating the transcription factor NFE2L2/NRF2. Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates the expression of genes encoding antioxidants, xenobiotic detoxification enzymes, and drug efflux pumps, and confers cytoprotection against oxidative stress and xenobiotics in normal cells. KEAP1 negatively regulates NRF2 activity by targeting it to proteasomal degradation. KEAP1 acts as a substrate adapter protein for the E3 ligase ubiquitin protein complex formed by CUL3 and RBX1 proteins which mediate the ubiquitination and proteasome destruction of NRF2. KEAP1 also targets PGAM5 which is a central mediator of programmed necrosis induced by TNF and reactive oxygen species, so again KEAP1 plays an important role ultimately in cell survival and adaptation to its microenvironment. KEAP1 is widely expressed in many tissues, most strongly in muscle tissues and appears to shuttle from the cytoplasm to the nucleus depending upon the cellular context.

ALT Names :

Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, INrf2

Immunogen :

Recombinant protein corresponding to mouse Keap1.

Package Size :

100 μg

Uses :

Western Blotting, Flow Cytometry, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt