Acylation Stimulating Protein Antibody, clone 4H3 | EMD Millipore MABS449 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Acylation Stimulating Protein Antibody, clone 4H3

catalog :

MABS449

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4H3

reactivity :

human

application :

western blot, ELISA

product information

Catalog Number :

MABS449

Subcategory :

Cell Signaling

Product Name :

Anti-Acylation Stimulating Protein Antibody, clone 4H3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01024

Host Name :

Mouse

Antigen :

CPAMD1

Clone :

4H3

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Acylation Stimulating Protein Antibody, clone 4H3

Cross Reactivity :

Human

Background :

The protein called Acylation stimulating protein (ASP) is a cleavage fragment protein from the Complement C3 gene. C3 plays a central role in the activation of the complement system. C3’s processing by C3 convertase is the central reaction in both classical and alternative complement pathways. ASP acts as an adipogenic hormone that stimulates triglyceride synthesis and glucose transport in adipocytes, and thus it helps regulate fat storage and triglyceride synthesis. ASP stimulates triglyceride synthesis via PLC, MAPK and AKT signaling pathways and ASP promotes the phosphorylation and internalization and recycling of Complement factor C5AR2. ASP is expressed in adipocytes and released into the plasma during both the fasting and postprandial periods. Increased levels of C3 and its cleavage product ASP are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.

ALT Names :

Complement C3, C3adesArg, C3, PZP-like alpha-2-macroglobulin domain-containing protein 1

Immunogen :

linear peptide corresponding to Human Acylation Stimulating Protein.

Package Size :

100 μg

Uses :

Western Blotting, ELISA

Storage :

Stable for 1 year at 2-8°C from date of receipt