WBP2 Antibody, clone 4C8H10 | EMD Millipore MABS441 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

WBP2 Antibody, clone 4C8H10

catalog :

MABS441

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4C8H10

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; fig 1d western blot; human; loading ...; fig 2b	Lim S, Lu S, Kang S, Tan H, Li Z, Adrian Wee Z, et al. Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2. Cancer Res. 2016;76:6278-6289 pubmed

product information

Catalog Number :

MABS441

Subcategory :

Cell Signaling

Product Name :

Anti-WBP2 Antibody, clone 4C8H10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q969T9

Host Name :

Mouse

Antigen :

WBP2

Clone :

4C8H10

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-WBP2 Antibody, clone 4C8H10

Cross Reactivity :

Human

Background :

WBP2 is a protein-protein interacting protein that binds to the WW domain of YAP1, WWP1 and WWP2 proteins. WW domain-containing proteins are found in most cells and play important roles in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. They are also upregulated in many cancers. WBP2 also interacts with the ubiquitin ligase proteins belonging to the NEDD4 family and appears to assist in the regulation of targeting proteins to proteasomes or lysosomes. Also in WBP2 knockout mice, the mice display abnormal brainstem and hearing development, indicating an important role in development as well.

ALT Names :

WW domain-binding protein 2, WBP-2

Immunogen :

GST-tagged full length recombinant protein corresponding to Human WBP2.

Package Size :

100 µL

Uses :

Western Blotting, Immunoprecipitation, Immunocytochemistry, Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt