EphA2 Antibody, clone SHM16 | EMD Millipore MABS412 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

EphA2 Antibody, clone SHM16

catalog :

MABS412

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SHM16

The same clone is also sold as:

BioLegend: 356801, 356803, 356802, 356804

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

MABS412

Subcategory :

Cell Signaling

Product Name :

Anti-EphA2 Antibody, clone SHM16

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P29317

Host Name :

Mouse

Antigen :

EphA2

Clone :

SHM16

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-EphA2 Antibody, clone SHM16

Cross Reactivity :

Human

Background :

EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptor A2 (EphA2), also known as Eck, is a Receptor tyrosine kinase activated by the ligand ephrin-A1/EFNA1 that regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Additioanally, EphA2 regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. EphA2 may also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. Recent studies have shown that during development, EphA2 may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Additioanally, it interacts with ligand ephrin-A5/EFNA5 and may regulate lens fiber cells shape, lens transparency development and maintenance. EphA2 has been suggested to play in importnat role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis druing its interaction with ephrin-A2/EFNA2 . Mutations in EphA2 have been associated with Cataract 6, multiple types (CTRCT6): an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness.

ALT Names :

Ephrin type-A receptor 2;Epithelial cell kinase;Tyrosine-protein kinase receptor ECK

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

100 μg

Uses :

Flow Cytometry

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.