APOL1 Antibody, clone 1D4 | EMD Millipore MABS385 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

APOL1 Antibody, clone 1D4

catalog :

MABS385

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D4

The same clone is also sold as:

MilliporeSigma: SAB5300144
ProMab: 20315
Abnova: MAB10491
Invitrogen: MA5-15487
OriGene: AM06309SU-N
LifeSpan Biosciences: LS-C108770

reactivity :

human

application :

western blot

product information

Catalog Number :

MABS385

Subcategory :

Cell Signaling

Product Name :

Anti-APOL1 Antibody, clone 1D4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O14791

Host Name :

Mouse

Antigen :

APOL1

Clone :

1D4

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-APOL1 Antibody, clone 1D4

Cross Reactivity :

Human

Background :

Apolipoprotein L1/Apolipoprotein L-1 (ApoL-1), or alternatively Apolipoprotein L (Apo-L/ApoL) is the protein encoded by the APOL1 gene in humans. Apolipoprotein L1 is one of the major carriers of cholesterol in the blood. It plays a role in the transport of cholesterol from the peripheral cells to the liver. It is a secreted protein expressed in liver, pancreas, lung, prostate, placenta and spleen. Apolipoprotein L1 is part of the HDL (high density lipoprotein) complex and Apolipoprotein L1 possesses both extra- and intra-cellular functions crucial in host defense and cellular homeostatic mechanisms. Alterations in Apolipoprotein L1 function due to genetic, environmental, and lifestyle factors have been associated with African sleeping sickness, atherosclerosis, lipid disorders, obesity, schizophrenia, cancer, and chronic kidney disease (CKD), yet much of its biological function remains unknown. Interesting, Apolipoprotein L1 has the ability to kill circulating trypanosomes in the blood. Trypanosomes cause a serious disease called sleeping sickness but in those individuals that have particular splice variants of Apolipoprotein L1 are spared sleeping sickness, however the variants are associated with an increased chance of kidney disease as a tradeoff. Apolipoprotein L1 appears important in autophagy and even as a cancer preventative as well. Recent research shows that increased intracellular levels of Apolipoprotein L1 can induce autophagy and autophagy-associated cell death but that Apolipoprotein L1 may protect kidney cells against renal cell carcinoma.

ALT Names :

APOL;APO-L;APOL-I;Apolipoprotein L1;Apolipoprotein L;Apolipoprotein L-I

Immunogen :

Purified recombinant fragment of human APOL1 expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.