NFKBIB Antibody, clone 7B4 | EMD Millipore MABS383 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NFKBIB Antibody, clone 7B4

catalog :

MABS383

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7B4

The same clone is also sold as:

OriGene: AM06491SU-N
LifeSpan Biosciences: LS-C169233
Cell Signaling Technology: 8635
ProMab: 30082
Invitrogen: MA5-15673

reactivity :

human

application :

western blot

product information

Catalog Number :

MABS383

Subcategory :

Cell Signaling

Product Name :

Anti-NFKBIB Antibody, clone 7B4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15653

Host Name :

Mouse

Antigen :

NFKBIB

Clone :

7B4

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-NFKBIB Antibody, clone 7B4

Cross Reactivity :

Human

Background :

NF-kappa-B inhibitor beta inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.Tissue specificity: Expressed in all tissues examined. The transcription factor NFkappaB (Nuclear Factor kappa B) is involved in the expression and regulation of a number of important cellular and physiological processes such as growth, development, apoptosis, immune and inflammatory response, and activation of various viral promoters including human immunodeficiency virus long terminal repeats. NFkappaB represents a group of structurally related and evolutionarily conserved proteins related to the proto-oncogene c-Rel with five members in mammals that include Rel (cRel), RelA (p65), RelB, NFkappaB1 (p50 and its precursor p105), and NFkappaB2 (p52 and its precursor p100). NFkappaB/Rel proteins exist as homo- or heterodimers to form transcriptionally competent or repressive complexes. Although most NFkappaB dimers are activators of transcription, the p50/50 and p52/52 homodimers can repress the transcription of their target genes. The p50/p65 heterodimer of NFkappaB is the most abundant in cells.

ALT Names :

IKBB;TRIP9;NFKBIB;NF-kappa-B inhibitor beta;NF-kappa-B;I-kappa-B-beta;IkB-B;IkB-beta;IkappaBbeta;Thyroid receptor-interacting protein 9;R-interacting protein 9;TRIP-9;NFKBIB

Immunogen :

Purified recombinant fragment of human NFKBIB expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.