LRP6 Antibody, clone 1C10 | EMD Millipore MABS341 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LRP6 Antibody, clone 1C10

catalog :

MABS341

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C10

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

citations: 1

Reference
Wang H, Yan Q, Yang T, Cheng H, Du J, Yoshioka K, et al. Scaffold protein JLP is critical for CD40 signaling in B lymphocytes. J Biol Chem. 2015;290:5256-66 pubmed publisher

product information

Catalog Number :

MABS341

Subcategory :

Cell Signaling

Product Name :

Anti-LRP6 Antibody, clone 1C10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O75581

Host Name :

Mouse

Antigen :

LRP6

Clone :

1C10

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-LRP6 Antibody, clone 1C10

Cross Reactivity :

Human;Rat;Mouse

Background :

Low density lipoprotein receptor-related protein 6, also known as LRP6, is a member of the low density Lipoprotein receptor gene family (LDLR). LDLR are cell surface proteins. LRP6 plays a crucial role in embryonic development by functioning as a co-receptor for the Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. LRP6 has a high affinity with the Dickkopf (DKK) family of antagonists which, when bound, block Wnt. When LRP6 binds to Wnt it is phosphlorated at multiple sites, which results in Axin, a scaffolding protein, being recruited to the cell membrane and β-catenin activation. β-catenin prevents Wnt and LRP6 from binding. LRP6 is associated with autosomal dominant coronary artery disease type 2. Mutations resulting in the omission of the extracellular domain of LPR6 results in constant activity whereas carboxy intracellular domain exclusion has a negative effect, resulting in the blocking of Wnt signaling.

ALT Names :

Low-density lipoprotein receptor-related protein 6;LRP-6

Immunogen :

Flag-tagged recombinant protein corresponding to human LRP6.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt