Gli3 Antibody, clone 5E1 | EMD Millipore MABS275 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Gli3 Antibody, clone 5E1

catalog :

MABS275

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5E1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

MABS275

Subcategory :

Cell Signaling

Product Name :

Anti-Gli3 Antibody, clone 5E1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10071

Host Name :

Mouse

Antigen :

Gli3

Clone :

5E1

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-Gli3 Antibody, clone 5E1

Cross Reactivity :

Human;Mouse

Background :

Gli3 can function as both a transcriptional activator and repressor of the sonic hedgehog (Shh) pathway. The full-length Gli3 form (GLI3FL) becomes an activator (GLI3A) after phosphorylation and nuclear translocation. The C-terminally truncated form (GLI3R), acts as a repressor. Proper balance between the Gli3 activator and the repressor specifies limb digit number and identity during development. In concert with TRPS1, Gli3 plays a role in activating chondrocyte proliferation. Gli3 is expressed in several normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. Gli3 defects are associated with Greig cephalo-poly-syndactyly syndrome (GCPS), Pallister-Hall syndrome (PHS), polydactyly postaxial type A1 (PAPA1), polydactyly postaxial type B polydactyly (PAPB), and polydactyly preaxial type 4 (POP4).

ALT Names :

Transcriptional activator GLI3;GLI3 form of 190 kDa;GLI3-190;GLI3FL;GLI3 C-terminally truncated form;GLI3 form of 83 kDa;GLI3-83

Immunogen :

Recombinant protein corresponding to the putative repressive motif of human GLI3.

Specificity :

This antibody recognizes the truncated, repressor form and the full length protein of human Gli3.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt