LRP6, clone A59, Ectodomain | EMD Millipore MABS274 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LRP6, clone A59, Ectodomain

catalog :

MABS274

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A59

reactivity :

human

application :

immunocytochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

MABS274

Subcategory :

Cell Signaling

Product Name :

Anti-LRP6, clone A59, Ectodomain

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O75581

Host Name :

Mouse

Antigen :

LRP6

Clone :

A59

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-LRP6, clone A59, Ectodomain

Cross Reactivity :

Human

Background :

Low density lipoprotein receptor-related protein 6, also known as LRP6, is a member of the low density Lipoprotein receptor gene family (LDLR). LDLR are cell surface proteins. LRP6 plays a crucial role in embryonic development by functioning as a co-receptor for the Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. LRP6 has a high affinity with the Dickkopf (DKK) family of antagonists which, when bound, block Wnt. When LRP6 binds to Wnt it is phosphlorated at multiple sites, which results in Axin, a scaffolding protein, being recruited to the cell membrane and β-catenin activation. β-catenin prevents Wnt and LRP6 from binding. LRP6 is associated with autosomal dominant coronary artery disease type 2. Mutations resulting in the omission of the extracellular domain of LPR6 results in constant activity whereas carboxy intracellular domain exclusion has a negative effect, resulting in the blocking of Wnt signaling.

ALT Names :

Low-density lipoprotein receptor-related protein 6, LRP-6

Immunogen :

Purified protein corresponding to the ectodomain domain of human LRP6.

Package Size :

100 μg

Uses :

Flow Cytometry, Immunoprecipitation, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt