v-Src Antibody, clone 327 | EMD Millipore MABS193 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

v-Src Antibody, clone 327

catalog :

MABS193

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

327

The same clone is also sold as:

Abcam: ab16885

reactivity :

African green monkey, human, mouse

application :

western blot, immunoprecipitation

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 1e	Fahrenkamp D, de Leur H, KÃ¼ster A, Chatain N, MÃ¼ller Newen G. Src family kinases interfere with dimerization of STAT5A through a phosphotyrosine-SH2 domain interaction. Cell Commun Signal. 2015;13:10 pubmed publisher
western blot; African green monkey	Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, et al. Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5. J Biol Chem. 2014;289:19627-36 pubmed publisher
western blot; human; 1:1000	Joannes A, Grelet S, Duca L, Gilles C, Kileztky C, Dalstein V, et al. Fhit regulates EMT targets through an EGFR/Src/ERK/Slug signaling axis in human bronchial cells. Mol Cancer Res. 2014;12:775-83 pubmed publisher
western blot; mouse	Mobasher M, Gonzalez Rodriguez A, Santamaria B, Ramos S, Martin M, Goya L, et al. Protein tyrosine phosphatase 1B modulates GSK3?/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death Dis. 2013;4:e626 pubmed publisher
immunoprecipitation; human	Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, et al. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron. 2002;35:907-20 pubmed
	Sager R, Woodford M, Backe S, Makedon A, Baker Williams A, DiGregorio B, et al. Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. Cell Rep. 2019;26:1344-1356.e5 pubmed publisher

product information

Catalog Number :

MABS193

Subcategory :

Cell Signaling

Product Name :

Anti-v-Src Antibody, clone 327

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P12931

Host Name :

Mouse

Antigen :

v-Src

Clone :

327

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-v-Src Antibody, clone 327

Cross Reactivity :

Mouse

Background :

v-Src is the product of the Rous sarcoma virus (RSV) oncogene, and functions as a non-receptor tyrosine kinase belonging to the family of Src proteins. Srcs are typically activated by dimerized cell surface receptors such as integrins, receptor tyrosine kinases, and cytokine receptors. Activated Src kinases phosphorylate the cytoplasmic domains of these receptors enabling interaction between these receptors and their downstream effector molecules. Src proteins are involved in many cellular processs such as apoptosis, immunity, gene expression, cell adhesion, cell migration, and cell transformation. Previous studies have reported that v-Src plays an important role in tumorigenesis.

ALT Names :

Proto-oncogene tyrosine-protein kinase Src;Proto-oncogene c-Src;pp60c-src;p60-Src

Immunogen :

Recombinant protein corresponding to purified pp60src from bacterial recombinants which direct the synthesis of v-Src.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt