IGF-IR Antibody, clone αIR3 (Azide Free) | EMD Millipore MABS192 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IGF-IR Antibody, clone αIR3 (Azide Free)

catalog :

MABS192

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

?IR3

reactivity :

human, rat

application :

immunocytochemistry, flow cytometry

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Gusscott S, Jenkins C, Lam S, Giambra V, Pollak M, Weng A. IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias. PLoS ONE. 2016;11:e0161158 pubmed publisher
immunocytochemistry; rat; 1:100	Chen Y, Zhang J, Shen L, Qi Q, Cheng X, Zhong Z, et al. Schwann cells induce Proliferation and Migration of Oligodendrocyte Precursor Cells Through Secretion of PDGF-AA and FGF-2. J Mol Neurosci. 2015;56:999-1008 pubmed publisher
	Malaguarnera R, Nicolosi M, Sacco A, Morcavallo A, Vella V, Voci C, et al. Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. Oncotarget. 2015;6:16084-105 pubmed

product information

Catalog Number :

MABS192

Subcategory :

Cell Structure

Product Name :

Anti-IGF-IR Antibody, clone αIR3 (Azide Free)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08069

Host Name :

Mouse

Antigen :

IGF-IR

Clone :

αIR3

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-IGF-IR Antibody, clone αIR3 (Azide Free)

Cross Reactivity :

Human

Background :

The insulin-like growth factors (IGFs) or somatomedins are mitogenic peptides present in the plasma of human, rat, and other species. Two distinct but chemically related IGFs have been purified from human plasma: IGF-I (Somatomedin C) and IGF-II. They are single chain polypeptides with molecular weights of 7,640 and 7,471, respectively. Types I and II IGF receptors differ in their structure and in their peptide binding specificity. Type I IGF receptors are structurally homologous to insulin receptors and contain alpha-subunits (MW = 130,000) that bind peptide, and beta-subunits (MW = 90,000), which have intrinsic tyrosine kinase activity. The protein-tyrosine kinase activity of the insulin receptor and, presumably the IGF-I receptor, is required for insulin to stimulate all of its biological responses in cells. MABS192 is constituted as azide-free.

ALT Names :

Insulin-like growth factor 1 receptor;Insulin-like growth factor I receptor;IGF-I receptor;CD221

Immunogen :

Partially purified human placenta IGF-1 receptor

Package Size :

100 µL

Uses :

Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.