Ubch9 Antibody | EMD Millipore MABS17 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Ubch9 Antibody

catalog :

MABS17

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

15F1.1

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000	Hans F, Fiesel F, Strong J, J ckel S, Rasse T, Geisler S, et al. UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. J Biol Chem. 2014;289:19164-79 pubmed publisher
	Lee M, Skoura A, Park E, Landskroner Eiger S, Jozsef L, Luciano A, et al. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development. 2014;141:1465-72 pubmed publisher
	Holen I, Whitworth J, Nutter F, Evans A, Brown H, Lefley D, et al. Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo. Breast Cancer Res. 2012;14:R86 pubmed
	Edkins A, Borland G, Acharya M, Cogdell R, Ozanne B, Cushley W. Differential regulation of monocyte cytokine release by ?V and ?(2) integrins that bind CD23. Immunology. 2012;136:241-51 pubmed publisher
	Zhang H, Li Z, Viklund E, Stromblad S. P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration. J Cell Biol. 2002;158:1287-97 pubmed

product information

Catalog Number :

MABS17

Subcategory :

Metabolism

Product Name :

Anti-Ubch9 Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q969T4

Host Name :

Mouse

Antigen :

Ubch9

Clone :

15F1.1

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Ubch9 Antibody

Cross Reactivity :

Mouse;Human

Background :

SUMO conjugation to target proteins is mediated by a different, but analogous, pathway to ubiquitinylation. UbcH9 is a SUMO conjugating enzyme that mediates the conjugation of SUMO-1 to a number of proteins including RanGAP1, IκBα and PML. It is known to interact directly with proteins that are modified by SUMOylation and may be important for substrate recognition. It appears that conjugation of SUMO-1 to IκBβ prevents subsequent ubiquitinylation and thus protects it from proteasomal degradation. Thus, while ubiquitinylation targets proteins for rapid degradation, SUMO-1 modification acts antagonistically to generate proteins resistant to degradation.

ALT Names :

Ubiquitin-conjugating enzyme E2 E3;UbcH9;Ubiquitin carrier protein E3;Ubiquitin-conjugating enzyme E2-23 kDa;Ubiquitin-protein ligase E3

Immunogen :

GST-tagged recombinant protein corresponding to human Ubch9.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt