phospho-GRK2 (Ser670) Antibody, clone 15G11.1 | EMD Millipore MABS155 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-GRK2 (Ser670) Antibody, clone 15G11.1

catalog :

MABS155

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

15G11.1

reactivity :

human

application :

western blot, immunoprecipitation

product information

Catalog Number :

MABS155

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-GRK2 (Ser670) Antibody, clone 15G11.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P25098

Host Name :

Mouse

Antigen :

phospho-GRK2 (Ser670)

Clone :

15G11.1

Conjugate :

Unconjugated

Isotype :

IgG2bκ

Product Description :

Anti-phospho-GRK2 (Ser670) Antibody, clone 15G11.1

Cross Reactivity :

Human

Background :

G-protein coupled receptor kinase 2 (Grk2), also known as BARK or BARK1, is a member of the large family of GRK kinases that phosphorylate G-protein coupled receptors (GPCR), resulting in the recruitment of arrestins to the cytoplasmic domains of GPCR’s and subsequent internalization of these receptors by endocytosis. GRK2 is ubiquitously expressed, and modulates diverse cellular processes through association with a number of non-receptor substrates. GRK2 regulates actin dynamics and cell motililty through interaction with radixin, tubilin, and ezrin. In addition, Grk2 may play a role in the signaling of TGFβ by blocking the nuclear translocation of Smad2 and Smad3 proteins. It has also been shown that Grk2 may play a role in the hedgehog signaling pathway during embryonic development, by modulating the signaling of the atypical G-protein coupled receptor Smo. Grk2 is inactivated by phosphorylation of ser670 by ERK. It is also phosphorylated by PKC and Src, depending on the cellular context.

ALT Names :

Beta-adrenergic receptor kinase 1;Beta-ARK-1;G-protein coupled receptor kinase 2

Immunogen :

KLH-conjugated linear peptide corresponding to human GRK2 phosphorylated at Ser670.

Specificity :

This antibody recognizes GRK2 phosphorylated at Ser670.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation;Peptide Inhibition Assay

Storage :

Stable for 1 year at 2-8°C from date of receipt