IRS-2 Antibody, clone 9.5.2 | EMD Millipore MABS15 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IRS-2 Antibody, clone 9.5.2

catalog :

MABS15

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9.5.2

reactivity :

human, mouse, rat

application :

western blot, western blot knockout validation

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; 1:2000; loading ...; fig 7a	Kubota N, Kubota T, Kajiwara E, Iwamura T, Kumagai H, Watanabe T, et al. Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity. Nat Commun. 2016;7:12977 pubmed publisher
western blot; rat; 1:2000; loading ...; fig 7	Sun Z, Zhan L, Liang L, Sui H, Zheng L, Sun X, et al. ZiBu PiYin recipe prevents diabetes-associated cognitive decline in rats: possible involvement of ameliorating mitochondrial dysfunction, insulin resistance pathway and histopathological changes. BMC Complement Altern Med. 2016;16:200 pubmed publisher
western blot; human	Blaabjerg L, Christensen G, Matsumoto M, van der Meulen T, Huising M, Billestrup N, et al. CRFR1 activation protects against cytokine-induced Î²-cell death. J Mol Endocrinol. 2014;53:417-27 pubmed publisher
western blot; human	Neukamm S, Ott J, Dammeier S, Lehmann R, Haring H, Schleicher E, et al. Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation. J Biol Chem. 2013;288:16403-15 pubmed publisher
	Kubota T, Inoue M, Kubota N, Takamoto I, Mineyama T, Iwayama K, et al. Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. Nat Commun. 2018;9:4863 pubmed publisher
	Lao Peregrín C, Ballesteros J, Fernández M, Zamora Moratalla A, Saavedra A, Gomez Lazaro M, et al. Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling. Addict Biol. 2017;22:1706-1718 pubmed publisher
	Chen J, Liang L, Zhan L, Zhou Y, Zheng L, Sun X, et al. ZiBuPiYin recipe protects db/db mice from diabetes-associated cognitive decline through improving multiple pathological changes. PLoS ONE. 2014;9:e91680 pubmed publisher
	Hoxhaj G, Dissanayake K, MacKintosh C. Effect of IRS4 levels on PI 3-kinase signalling. PLoS ONE. 2013;8:e73327 pubmed publisher
	Choi H, Yoon Y, Kwon Y, Lee Y, Chae S, Hwang D, et al. Patterns of gene and metabolite define the effects of extracellular osmolality on kidney collecting duct. J Proteome Res. 2012;11:3816-28 pubmed publisher

product information

Catalog Number :

MABS15

Subcategory :

Cell Signaling

Product Name :

Anti-IRS-2 Antibody, clone 9.5.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P81122

Host Name :

Mouse

Antigen :

IRS-2

Clone :

9.5.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-IRS-2 Antibody, clone 9.5.2

Cross Reactivity :

Mouse;Rat

Background :

Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic beta cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.

ALT Names :

insulin receptor substrate 2

Immunogen :

KLH-conjugated linear peptide corresponding to mouse IRS-2.

Specificity :

This antibody recognizes IRS-2.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt