phospho-Sin1 (Ser385) Antibody | EMD Millipore MABS145 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Sin1 (Ser385) Antibody

catalog :

MABS145

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

11D1.1

reactivity :

human

application :

western blot

product information

Catalog Number :

MABS145

Subcategory :

Metabolism

Product Name :

Anti-phospho-Sin1 (Ser385) Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9BPZ7

Host Name :

Mouse

Antigen :

phospho-Sin1 (Ser385)

Clone :

11D1.1

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-phospho-Sin1 (Ser385) Antibody

Cross Reactivity :

Human

Background :

Sin1 (stress-activated protein kinase (SAPK)-interacting protein 1, MAPKAP1) is an essential component of the Torc2 complex. mTORC2 is comprised of mTOR, a large Ser/Thr protein kinase along with Sin1, GbL (mLST8), Protor1, Protor2, and Rictor. The complex that is activated primarily downstream of PI3 Kinase and is known to affect cell proliferation and survival primarily by phosphorylating Akt on Ser473. Additionally, the mTORC2 complex is also known to effect cytoskeletal organization and migration by exerting its effects through Rac, Rho, and PKC. Sin1 is also known to directly interact without proteins that include Ras, SPAKs, and JNK. Uniprot.org states 6 different isoforms of Sin1, each with its own observed molecular weight. It is suggested to be involved in metabolic signaling.

ALT Names :

Target of rapamycin complex 2 subunit MAPKAP1;TORC2 subunit MAPKAP1;Mitogen-activated protein kinase 2-associated protein 1;Stress-activated map kinase-interacting protein 1;SAPK-interacting protein 1;mSIN1

Immunogen :

Linear peptide corresponding to mouse Sin1 phosphorylated at Ser385.

Specificity :

This antibody recognizes Sin1 phosphorylated at Ser385.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt