CHIP Antibody, clone 2F2.1 | EMD Millipore MABS133 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CHIP Antibody, clone 2F2.1

catalog :

MABS133

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2F2.1

reactivity :

human, mouse

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABS133

Subcategory :

Cell Signaling

Product Name :

Anti-CHIP Antibody, clone 2F2.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UNE7

Host Name :

Mouse

Antigen :

CHIP

Clone :

2F2.1

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-CHIP Antibody, clone 2F2.1

Cross Reactivity :

Human

Background :

Carboxyl-terminus of Hsc70 interacting protein (CHIP) is an E3 ubiquitin ligase. It has been detected in the heart, pancreas, brain, placenta, liver, lung, kidney, and skeletal muscle. CHIP is a multidomain protein containing an N-terminal TPR domain and a C-terminal U box domain both of which may interact with chaperones such as Hsc70 and Hsp70. CHIP is mainly involved with recognizing and marking misfolded proteins for degradation; however, CHIP is a unique E3 protein in requiring chaperone association with target proteins before marking them for ubiquitination. CHIP is therefore important for cell survival as it prevents the accumulation of non-functional proteins in the cell which could potentially produce cytotoxic effects. Previous studies have also suggested that CHIP may be involved in Toll-like receptor (4 and 6) signaling by activating downstream targets such as Src and PKCζ.

ALT Names :

E3 ubiquitin-protein ligase CHIP;Antigen NY-CO-7;CLL-associated antigen KW-8;Carboxy terminus of Hsp70-interacting protein;STIP1 homology and U box-containing protein 1

Immunogen :

GST-tagged recombinant protein corresponding to mouse CHIP.

Package Size :

100 μg

Uses :

Immunohistochemistry;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt