K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12 | EMD Millipore MABN88 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12

catalog :

MABN88

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N1/12

The same clone is also sold as:

OriGene: 75-013, 73-013
BioLegend: 821701
Neuromab: 75-013, 73-013
Abcam: ab134300

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - free floating section

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000	Chugh D, Ali I, Bakochi A, Bahonjic E, Etholm L, Ekdahl C. Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2. PLoS ONE. 2015;10:e0132366 pubmed publisher
immunohistochemistry - free floating section; mouse; 1:300	Markkanen M, Karhunen T, Llano O, Ludwig A, Rivera C, Uvarov P, et al. Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS. J Comp Neurol. 2014;522:1897-914 pubmed publisher

product information

Catalog Number :

MABN88

Subcategory :

Neuroscience

Product Name :

Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q63633

Host Name :

Mouse

Antigen :

K+/Cl- Cotransporter (KCC2)

Clone :

N1/12

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12

Cross Reactivity :

Rat;Human;Rat

Background :

KCC2 is a member of the cation-chloride cotransporter gene family. It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.

ALT Names :

Electroneutral potassium-chloride cotransporter 2;Erythroid K-Cl cotransporter 2;Neuronal K-Cl cotransporter;electroneural potassium-chloride cotransporter 2;solute carrier family 12;potassium-chloride transporter), member 5

Immunogen :

Recombinant protein corresponding to rat KCC2.

Specificity :

This antibody recognizes KCC2

Package Size :

100 μg

Uses :

Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt