TREM-2 Antibody, clone 78 | EMD Millipore MABN755 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TREM-2 Antibody, clone 78

catalog :

MABN755

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 1

Reference
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher

product information

Catalog Number :

MABN755

Subcategory :

Neuroscience

Product Name :

Anti-TREM-2 Antibody, clone 78

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q99NH8

Host Name :

Rat

Antigen :

Trem2

Clone :

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-TREM-2 Antibody, clone 78

Cross Reactivity :

Human, Rat, Mouse

Background :

TREM-2, also known as Triggering receptor expressed on myeloid cells 2 or Triggering receptor expressed on monocytes 2, and encoded by the gene Trem2/Trem2a/Trem2b/Trem2c, is a protein that forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. TREM-2 may also have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 is localized to the cell membrane and is a single pass membrane protein. TREM-2 is expressed in immune cells such as microglia and monocytes but the expression varies depending upon the exact tissue and location within the tissue. Defects in TREM-2 may be associated in humans with frontotemporal dementia, Nasu-Hakola disease, and recently an increase risk of Alzheimer's disease.

ALT Names :

Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2

Immunogen :

Recombinant protein corresponding to mouse TREM-2.

Package Size :

100 μg

Uses :

Western Blotting, Immunocytochemistry, Flow Cytometry, Inhibition, Immunoprecipitation

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.