CCL2 Antibody, clone 2D8 | EMD Millipore MABN712 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CCL2 Antibody, clone 2D8

catalog :

MABN712

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D8

The same clone is also sold as:

LifeSpan Biosciences: LS-C169178, LS-C359320
Invitrogen: MA5-17040
OriGene: AM06749PU-N, TA336914
ProMab: 30351
Novus Biologicals: NBP2-80618, NBP2-22115

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse	Sun L, Hua Y, Vergarajauregui S, Diab H, Puertollano R. Novel Role of TRPML2 in the Regulation of the Innate Immune Response. J Immunol. 2015;195:4922-32 pubmed publisher
immunohistochemistry - paraffin section; mouse	Sarr D, Bracken T, Owino S, Cooper C, Smith G, Nagy T, et al. Differential roles of inflammation and apoptosis in initiation of mid-gestational abortion in malaria-infected C57BL/6 and A/J mice. Placenta. 2015;36:738-49 pubmed publisher

product information

Catalog Number :

MABN712

Subcategory :

Neuroscience

Product Name :

Anti-CCL2 Antibody, clone 2D8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P13500

Host Name :

Mouse

Antigen :

CCL2

Clone :

2D8

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-CCL2 Antibody, clone 2D8

Cross Reactivity :

Human;Mouse;Rat;Monkey

Background :

CCL2, Chemokine (C-C motif) ligand 2, or alternatively known as Monocyte chemotactic protein 1 (MCP-1), Monocyte chemotactic and activating factor (MCAF), Monocyte chemoattractant protein 1, Monocyte secretory protein JE, Small-inducible cytokine A2, HC11, and C-C motif chemokine 2 is encoded by the human gene named CCL2/MCP1/SCYA2. CCL2 is a chemokine produced by endothelial cells that attracts memory T cells, monocytes, dendritic cells, and basophils but not neutrophils or eosinophils to sites of inflammation produced by either tissue inquiry or infection. CCL2 also bolsters monocytes anti-tumor activity, and because it is chemotactic for monocytes, CCL2 has been implicated in inflammatory diseases where monocytic invasions have occurred such as in psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is a bifunctional molecule as well; the whole molecule is a basophil activator but removal of the N-terminal portion converts the molecule into an exclusive eosinophil chemoattractant. CCL2 can also be found expressed at the sites of tooth eruption and bone degradation and is expressed by both osteoclasts and osteoblasts. CCL2 is also expressed in neurons, astrocytes and microglia and its role in neuroinflammation is established. CCL2 expression in glial and neurons is increased in epilepsy, brain ischemia, Alzheimer’s disease, brain injury and experimental autoimmune encephalomyelitis. Finally, CCL2 plays a role in vascular complications associated with type II diabetes and in the production of amylin which contributes to insulin resistance in obesity, which is also associated with type II diabetes. EMD-Millipore’s Anti-CCL2 mouse monoclonal antibody has been tested in western blot against recombinant protein and cell lysates from A549, HeLa, Raw264.7, L1210, C6, and COS7 cell lines.

ALT Names :

C-C motif chemokine 2;Monocyte chemoattractant protein 1;Monocyte chemotactic and activating factor;Monocyte chemotactic protein 1;Monocyte secretory protein JE;Small-inducible cytokine A2

Immunogen :

Purified recombinant fragment of human CCL2 expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting;Immunofluorescence;Immunohistochemistry;Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt