GluR2 Antibody, clone L21/32 | EMD Millipore MABN71 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GluR2 Antibody, clone L21/32

catalog :

MABN71

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

L21/32

The same clone is also sold as:

OriGene: 75-002, 73-002
BioLegend: 810502, 810501, 810503, 810504
Abcam: ab192760

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:5000; fig 6a	McQuail J, Beas B, Kelly K, Simpson K, Frazier C, Setlow B, et al. NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline. J Neurosci. 2016;36:12537-12548 pubmed
western blot; mouse; 1:500; fig s2	Sun X, Li L, Liu F, Huang Z, Bean J, Jiao H, et al. Lrp4 in astrocytes modulates glutamatergic transmission. Nat Neurosci. 2016;19:1010-8 pubmed publisher
western blot; human; 1:200	Jensen M, Arvaniti M, Mikkelsen J, Michalski D, Pinborg L, HÃ¤rtig W, et al. Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease. Neurobiol Aging. 2015;36:1629-1638 pubmed publisher
	Sutton L, Orlandi C, Song C, Oh W, Muntean B, Xie K, et al. Orphan receptor GPR158 controls stress-induced depression. elife. 2018;7: pubmed publisher
	Arvaniti M, Jensen M, Soni N, Wang H, Klein A, Thiriet N, et al. Functional interaction between Lypd6 and nicotinic acetylcholine receptors. J Neurochem. 2016;138:806-20 pubmed publisher
	Warmus B, Sekar D, McCutchen E, Schellenberg G, Roberts R, McMahon L, et al. Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia. J Neurosci. 2014;34:16482-95 pubmed publisher
	Gong K, Kung L, Magni G, Bhargava A, Jasmin L. Increased response to glutamate in small diameter dorsal root ganglion neurons after sciatic nerve injury. PLoS ONE. 2014;9:e95491 pubmed publisher
	Thomsen M, Cinar B, Jensen M, Lyukmanova E, Shulepko M, Tsetlin V, et al. Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated. Brain Struct Funct. 2014;219:1923-34 pubmed publisher
	Li X, DeJoseph M, Urban J, Bahi A, Dreyer J, Meredith G, et al. Different roles of BDNF in nucleus accumbens core versus shell during the incubation of cue-induced cocaine craving and its long-term maintenance. J Neurosci. 2013;33:1130-42 pubmed publisher
	Orozco D, Tahirovic S, Rentzsch K, Schwenk B, Haass C, Edbauer D. Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. EMBO Rep. 2012;13:759-64 pubmed publisher
	Li X, Wolf M. Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens. Eur J Neurosci. 2011;34:190-8 pubmed publisher

product information

Catalog Number :

MABN71

Subcategory :

Neuroscience

Product Name :

Anti-GluR2 Antibody, clone L21/32

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42262

Host Name :

Mouse

Antigen :

GluR2

Clone :

L21/32

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-GluR2 Antibody, clone L21/32

Cross Reactivity :

Rat;Mouse;Human

Background :

Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. In GluR2, it is occupied by an Arg residue. It has been shown experimentally that the presence of Arg in this position blocks Ca2+ ion permeability, while a Gln does not. Relative calcium permeability in AMPA receptor channels may be significant in pathological neurotoxic damage and long term changes in nervous system responses.

ALT Names :

glutamate receptor, ionotropic, AMPA 2;glutamate receptor 2;Glutamate receptor ionotropic, AMPA 2;AMPA-selective glutamate receptor 2

Immunogen :

Recombinant protein corresponding to human GluR2.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt