ETV5 Antibody, clone 3H3 | EMD Millipore MABN683 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ETV5 Antibody, clone 3H3

catalog :

MABN683

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3H3

The same clone is also sold as:

LifeSpan Biosciences: LS-B10724
OriGene: AM06457SU-N
ProMab: 30055
Invitrogen: MA5-15646
Abnova: MAB16421

reactivity :

human

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000; loading ...; fig s3	Cottard F, Madi Berthélémy P, Erdmann E, Schaff Wendling F, Keime C, Ye T, et al. Dual effects of constitutively active androgen receptor and full-length androgen receptor for N-cadherin regulation in prostate cancer. Oncotarget. 2017;8:72008-72020 pubmed publisher

product information

Catalog Number :

MABN683

Subcategory :

Neuroscience

Product Name :

Anti-ETV5 Antibody, clone 3H3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P41161

Host Name :

Mouse

Antigen :

ETV5

Clone :

3H3

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-ETV5 Antibody, clone 3H3

Cross Reactivity :

Human

Background :

ETS family members play an important role in mammalian development and have been implicated in the regulation of gene expression during a variety of biologic processes including cell growth and differentiation. Defects or deficiencies, as well as overexpression of ETS family members can have major developmental effects as well as aid in tumor development. ETS translocation variant 5 protein (ETV5) also known as ETS-related protein ERM is a nuclear localized protein that binds to DNA sequences containing the consensus nucleotide core sequence of GGAA and is a member of the very large ETS transcription factor family. Early experiments in worms suggested that ETV5 might play a role in the development of the dopaminergic nervous system; however that has not proved to be the case in mammals. However, more recent research has indicated ETV5 playing an important role in the development of reproduction and in the development of ovarian cancer. ETV5 controls the expression of critical prostaglandins needed for ovarian development and ETV5 deficient mice show complex infertility phenotypes both in males and females. In males, the infertility phenotype exhibited by ETV5 deficiency is sexually dimorphic, and it involves both somatic cells and germ cells. In Etv5-/- female mice, the problem is more complicated by hormonal involvement and results in more a complex phenotype. EMD-Millipore’s Anti-ETV5 mouse monoclonal antibody has been tested in western blot against Jurkat, NIH3T3 and MCF-7 cell lysates.

ALT Names :

ETS translocation variant 5;Ets-related protein ERM;ETV5

Immunogen :

Purified recombinant fragment of human ETV5 expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.