TrkA Antibody, clone 6B2 | EMD Millipore MABN681 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TrkA Antibody, clone 6B2

catalog :

MABN681

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6B2

The same clone is also sold as:

ProMab: 20337
LifeSpan Biosciences: LS-C108757
Invitrogen: MA5-15509
Abnova: MAB10431
OriGene: AM06329SU-N

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Reference
Li C, Götz J. Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn. J Alzheimers Dis. 2018;64:205-221 pubmed publisher

product information

Catalog Number :

MABN681

Subcategory :

Neuroscience

Product Name :

Anti-TrkA Antibody, clone 6B2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P04629

Host Name :

Mouse

Antigen :

TrkA

Clone :

6B2

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-TrkA Antibody, clone 6B2

Cross Reactivity :

Human;Rat

Background :

TrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.

ALT Names :

High affinity nerve growth factor receptor;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;Trk-A;gp140trk;p140-TrkA

Immunogen :

Purified recombinant extracellular fragment of TrkA expressed in HEK293 cells.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry;Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.