ARNTL Antibody, clone 1C5 | EMD Millipore MABN673 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ARNTL Antibody, clone 1C5

catalog :

MABN673

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C5

The same clone is also sold as:

OriGene: AM06432SU-N
Invitrogen: MA5-15624
LifeSpan Biosciences: LS-B4159
ProMab: 30033
Abnova: MAB10493
MyBioSource: MBS850286

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABN673

Subcategory :

Neuroscience

Product Name :

Anti-ARNTL Antibody, clone 1C5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O00327

Host Name :

Mouse

Antigen :

ARNTL

Clone :

1C5

Conjugate :

Ascites

Isotype :

IgG1

Product Description :

Anti-ARNTL Antibody, clone 1C5

Cross Reactivity :

Human

Background :

Aryl hydrocarbon receptor nuclear translocator-like protein 1 or alternatively, Basic-helix-loop-helix PAS protein MOP3, Brain and muscle ARNT-like 1, Class E basic helix-loop-helix protein 5 (bHLHe5), Member of PAS protein 3, PAS domain-containing protein 3, bHLH-PAS protein JAP3, and encoded by the human gene ARNTL,BHLHE5, BMAL1, MOP3 or PASD3, is a protein belonging to the basic helix-loop-helix-PAS domain containing transcription factor family. ARNTL protein is important for the molecular mechanisms behind circadian rhythms as it interacts with a number of CLOCK (Circadian Locomotor Output Cycles Kaput) family members as well as CLOCK itself to promote transcription of a number of proteins of the circadian clock. ARNTL interacts with CRY and CRY2, PER, TIMELESS, and other clock related genes as well as non-CLOCK proteins such as HIF-1alpha (HIF1A) and SUMO3. ARNTL appears critical for proper function of rhythms, as only knockouts of ARNTL in mice generate mice that have upset biological clocks and a shorter lifespan. ARNTL is highly expressed in the adult brain as well as skeletal muscle and heart and ARNTL is a nuclear localized transcription activator. EMD-Millipore’s Anti-ARNTL mouse monoclonal antibody has been tested in western blot against recombinant transfected protein and in paraffin embedded immunohistochemistry on human spleen tissue sections.

ALT Names :

Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic-helix-loop-helix-PAS protein MOP3;Brain and muscle ARNT-like 1;Class E basic helix-loop-helix protein 5;Short name=bHLHe5;Member of PAS protein 3;PAS domain-containing protein 3;bHLH-PAS protein JAP3

Immunogen :

Purified recombinant fragment of human ARNTL expressed in E. Coli.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.