Amyloid beta fibrils, clone M64, Rabbit Monoclonal | EMD Millipore MABN637 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Amyloid beta fibrils, clone M64, Rabbit Monoclonal

catalog :

MABN637

quantity :

50 μg

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

M64

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

product information

Catalog Number :

MABN637

Subcategory :

Neuroscience

Product Name :

Anti-Amyloid beta fibrils, clone M64, Rabbit Monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05067

Host Name :

Rabbit

Antigen :

APP

Clone :

M64

Conjugate :

Purified

Purification Method :

Protein A purified

Isotype :

IgGκ

Product Description :

Anti-Amyloid beta fibrils, clone M64, Rabbit Monoclonal

Cross Reactivity :

Human

Background :

The protein named Amyloid beta A4, or ABPP, APP, APPI, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, or Protease nexin II (PN-II) protein and encoded by human gene A4/AD1 is a precursor to 14 peptides some of which are associated with neurological disease such as Alzheimer's Disease. In pathological conditions Amyloid beta A4 protein is the precursor for the disease associated proteins, Beta amyloid 40, and Beta amyloid 42, major components of plaques in Alzheimer’s Disease. APP plays a role in neuronal development and mediates aspects of axonal transport as well as neurite outgrowth. It is also involved in copper homeostasis/oxidative stress through copper ion reduction in neurons. MABN637 recognizes a specific conformation of residues 3-6 of the amyloid Aß peptide sequence (EFRH) found in amyloid fibrils. It does not recognize pyroglutamyl Aß at residue 3. It displays a distinct specificity from MABN638 on dot blots of Aß preparations. It also reacts with polyQ40 fibrils but not monomers, indicating that it recognizes a generic, sequence independent epitope. MABN640 on the other hand, recognizes a specific conformation of residues 2-7 of the amyloid Aß peptide sequence (AEFRHD) found in amyloid fibrils. It does not detectably react with APP, IAPP, a-synuclein or polyQ fibrils (Hatami, et al., manuscript in preparation). MABN637 is rapidly cleared from the circulation of mice after intravenous administration.

ALT Names :

Amyloid Beta, Amyloid B, Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP2, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C995.Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, C83, P3(42), P3(40), C80, Gamma-secretase C-terminal fragment 59, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), C31

Immunogen :

Corresponding to the Beta Amyloid Protein 42 (residue 3-6) of Human Amyloid beta fibrils.

Package Size :

50 μg

Uses :

Dot Blot, Western Blotting, Immunohistochemistry, Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt