LRRK2 Antibody, clone 8G10 | EMD Millipore MABN636 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LRRK2 Antibody, clone 8G10

catalog :

MABN636

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8G10

The same clone is also sold as:

Neuromab: 73-308, 75-308
BioLegend: 844402, 844401

reactivity :

human, rat

application :

western blot, immunohistochemistry, flow cytometry

citations: 21

Published Application/Species/Sample/Dilution	Reference
flow cytometry; rat	Boopathy A, Che P, Somasuntharam I, Fiore V, Cabigas E, Ban K, et al. The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation. Biomaterials. 2014;35:8103-12 pubmed publisher
	Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. 2014;5:7540-8 pubmed
	Wang S, Sun W, Zhao Y, McEachern D, Meaux I, BarriÃ¨re C, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014;74:5855-65 pubmed publisher
	Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed publisher
	Guerzoni C, Amatori S, Giorgi L, Manara M, Landuzzi L, Lollini P, et al. An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas. BMC Cancer. 2014;14:137 pubmed publisher
	Sun F, Mao X, Xie L, Ding M, Shao B, Jin K. Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia. Aging Cell. 2013;12:978-87 pubmed publisher
	Huang B, Ray P, Iwasaki K, Tsuji Y. Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. FASEB J. 2013;27:3763-74 pubmed publisher
	Brizuela L, Ader I, Mazerolles C, Bocquet M, Malavaud B, Cuvillier O. First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. Mol Cancer Ther. 2012;11:1841-51 pubmed publisher
	Leopoldino A, Squarize C, Garcia C, Almeida L, Pestana C, Sobral L, et al. SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncol. 2012;48:1106-13 pubmed publisher
	Crose L, Etheridge K, Chen C, Belyea B, Talbot L, Bentley R, et al. FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. Clin Cancer Res. 2012;18:3780-90 pubmed publisher
	Hou X, Tashima Y, Stanley P. Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling. J Biol Chem. 2012;287:474-83 pubmed publisher
	Radi E, Formichi P, Di Maio G, Battisti C, Federico A. Oxidative stress-induced apoptosis in two patients with Alagille syndrome. J Neurol Sci. 2011;308:49-56 pubmed publisher
	Leonelli M, Martins D, Britto L. TRPV1 receptors modulate retinal development. Int J Dev Neurosci. 2011;29:405-13 pubmed publisher
	Zhou Y, Feng X, Koh D. Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase. Biochemistry. 2011;50:2850-9 pubmed publisher
	Kim E, Teh S, Yang J, Chow M, Teh H. TNFR2-deficient memory CD8 T cells provide superior protection against tumor cell growth. J Immunol. 2009;183:6051-7 pubmed publisher
	Shawgo M, Shelton S, Robertson J. Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II Jurkat cells. J Biol Chem. 2009;284:33447-55 pubmed publisher
	Shelton S, Shawgo M, Matthews S, Lu Y, Donnelly A, Szabla K, et al. KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol. 2009;76:1314-22 pubmed publisher
	Chen L, Redkar S, Bearss D, Wierda W, Gandhi V. Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood. 2009;114:4150-7 pubmed publisher
	Clement C, Dandepally S, Williams A, Ibeanu G. A synthetic analog of verbenachalcone potentiates NGF-induced neurite outgrowth and enhances cell survival in neuronal cell models. Neurosci Lett. 2009;459:157-61 pubmed publisher
	Stahl M, Uemura K, Ge C, Shi S, Tashima Y, Stanley P. Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem. 2008;283:13638-51 pubmed publisher
	Preyer M, Shu C, Wang J. Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals. Cell Death Differ. 2007;14:1139-48 pubmed

product information

Catalog Number :

MABN636

Subcategory :

Neuroscience

Product Name :

Anti-LRRK2 Antibody, clone 8G10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q5S007

Host Name :

Mouse

Antigen :

LRRK2

Clone :

8G10

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-LRRK2 Antibody, clone 8G10

Cross Reactivity :

Human

Background :

Leucine-rich repeat kinase 2 (LRRK2) is a 2,527 amino acid protein encoded by the PARK8 gene and belonging to the ROCO family of proteins. This protein family is characterized as having a unique interaction between the Roc domain and the intrinsic GTPase activity along with a COR domain. LRRK2 consists of 5 different domains; a tyrosine kinase-like MAPKKK-related domain, WD40 propeller motif repeats, a Roc (Ras-like small GTPase family) domain, a COR (C-terminal of Roc) domain, and an LRRK. LRRK2 is mainly localized to the cytoplasm and expression within tissue is most highly observed within the brain. It is found in lower levels within the liver, heart, lung, skeletal muscles, placenta, pancreas, and kidney. The exact function of LRRK2 is unknown; however mutations to any of the five domains are the most commonly known causes of Parkinson’s disease, both familial and sporadic. Further study of this protein may lead to a better understanding of the disease’s pathogenesis, as well as potential therapeutic markers.

ALT Names :

Leucine-rich repeat serine/threonine-protein kinase 2;Dardarin

Immunogen :

Recombinant protein corresponding to human LRRK2.

Specificity :

This antibody does not seem to recognize LRRK2 in mouse embryonic fibroblasts cell lysates, but recognizes LRRK2 in human lymphoblast cell lysates.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt