Huntingtin Antibody, clone 4A4.2 | EMD Millipore MABN60 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Huntingtin Antibody, clone 4A4.2

catalog :

MABN60

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A4.2

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABN60

Subcategory :

Neuroscience

Product Name :

Anti-Huntingtin Antibody, clone 4A4.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42858

Host Name :

Mouse

Antigen :

Huntingtin

Clone :

4A4.2

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Huntingtin Antibody, clone 4A4.2

Cross Reactivity :

Human;Rat

Background :

Huntington disease (HD) is a hereditary, progressive, neurodegenerative ailment characterized by personality changes, motor impairment and subcortical dementia. The molecular basis of the disease involves the expansion of the trinucleotide CAG, coding for polyglutamine in the first exon of a chromosome four gene (4p16.3), which normally produces a widely expressed 3136 a.a. (~350 kDa) protein Huntingtin with unclear function. The protein is found in the perinuclear region along with microtubules, and in the centrosomal region along with gamma-tubulin. Huntingtin is necessary for neuronal survival and is involved in synaptic vesicle trafficking, microtubule binding and may also have a role in apoptosis. In the HD condition, neuronal cells with the mutant form of huntingtin possess intranuclear aggregations of the N-terminal fragment, causing damaging inclusions in perinuclear locations and striatal neuron cell death. Huntingtin is known to interact with GAPDH, HAP-1, SP1 and TAFII130.

ALT Names :

Huntingtin;Huntington disease protein;HD protein

Immunogen :

Recombinant protein corresponding to human Huntingtin.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt